INTERACTION BETWEEN ASPIRIN AND PROSTAGLANDINS IN THE ISOLATED GUINEA-PIG TRACHEAL MUSCLE
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概要
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The effects of PGE<SUB>2</SUB> and PGF<SUB>2α</SUB> on the tonus of isolated guinea-pig tracheal chain were investigated and compared with those of histamine and acetylcholine. PGE<SUB>2</SUB> reduced tonus in normal resting state, but elevated tracheal tonus reduced by aspirin. Such PGE<SUB>2</SUB>-induced contractions did not exceed the initial resting tonus, and the magnitude and duration of the contractions progressively diminished with increase of PGE<SUB>2</SUB> concentrations. Aspirin produced neither relaxation nor contraction in the presence of a low dose of PGE<SUB>2</SUB>. Unlike PGE<SUB>2</SUB>, PGF<SUB>2α</SUB> produced a dose-related contraction in the normal tracheal chain, and the contractile response to PGF<SUB>2α</SUB> was markedly potentiated by aspirin. In the presence of PGF<SUB>2α</SUB>, aspirin no longer produced tracheal relaxation but produced a dose-related contraction. The contractile effect of histamine but not of acetylcholine was also potentiated by aspirin, but there was a slight difference between PGF<SUB>2α</SUB> and histamine in that the potentiation of action of PGF<SUB>2α</SUB> by aspirin was more easily diminished by PGE<SUB>2</SUB>. These results suggest that PGE<SUB>2</SUB> plays an important role in the maintenance of the resting tonus of the isolated guinea-pig tracheal chain, and in large doses it also acts as a tracheal relaxant and attenuates the tracheal responses to PGF<SUB>2α</SUB> and histamine.
- 社団法人 日本薬理学会の論文
著者
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Ono Takaharu
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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MOTOYAMA Yukio
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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SAKAI Shigeru
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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YONEDA Junko
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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KUMADA Shigenobu
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd.
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- POTENTIATING EFFECT OF PROSTAGLANDINS AND OTHER ANTIULCER DRUGS ON GASTRIC MUCOSAL DEFFENSIVE FACTORS
- INTERACTION BETWEEN ASPIRIN AND PROSTAGLANDINS IN THE ISOLATED GUINEA-PIG TRACHEAL MUSCLE
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