RELATIONSHIP BETWEEN SERUM GASTRIN LEVELS AND GASTRIC SECRETION IN HEIDENHAIN POUCH DOGS

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Relationship between serum gastrin levels and gastric secretion was studied in Heidenhain pouch dogs. Bethanecol and tetramethylammonium increased gastric secretion without any significant change in the serum immunoreactive gastrin (IRG) level. Histamine increased gastric secretion but decreased the serum IRG level. Tetragastrin evoked gastric secretion concomitantly with an elevation of the serum IRG level, and the relationship was significant. Food-intake promptly increased the serum IRG level which correlated with the increased gastric secretion. Except for the first 15-min value after food-intake, a better correlation was obtained and was almost the same as that with tetragastrin-stimulation. Hexamethonium reduced the food-induced secretion rate in parallel with reduction of the serum IRG level. Correlation between the secretion rate and serum IRG level after dosing was almost the same as that of the control. Atropine and secretin induced a stronger inhibition on the secretion rate than on the serum IRG level. Prostaglandin E/reduced the secretion rate, but produced no inhibitory effect on the serum IRG level. These results suggest that the food-induced gastric secretion in Heidenhain pouch dogs is due to the action of endogenous gastrin, and that hexamethonium and prostaglandin E<SUB>1</SUB> affect respectively the gastrin and parietal cells. Atropine and secretin affect both parietal and gastrin cells.
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