アミノ配糖体薬剤の急速静注による聴器・腎障害に関する実験的研究

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Ototoxicity and nephrotoxicity of aminoglycoside antibiotics (dibekacin, gentamicin and kanamycin) by rapid intravenous injection were histopathologically compared with those by intramuscular injection in 83 rabbits. The concentration of aminoglycoside antibiotics in serum and perilymph, after administration of two different routes was also comparatively assessed. The doses of antibiotics were 50mg/kg for dibekacin, 30mg/kg for gentamicin, and 100mg/kg for kanamycin. These antibiotics were administered for 30 days, and all animals were sacrificed 10 days after the last injection for histopathological studies.The concentration of the antibiotics in serum and perilymph was determined through a single administration of two different routes in doses of 50mg/kg for dibekacin and 100mg/kg for kanamycin.The results revealed that, although the peak serum level of antibiotics by the rapid intravenous injection was significantly much higher than that by the intramuscular injection, no differences in the transfer of antibiotics into perilymph and in degrees or patterns of inner ear damage or renal damage by antibiotics were seen between the two different routes. In other words, the results of the present study did not support the conventional idea that, the higher the peak blood levels of the aminoglycoside antibiotics, the more the damage in inner ear or kidney tends to take place.
社団法人日本耳鼻咽喉科学会の論文