音負荷後の家兎外有毛細胞核下部の経時的変化について

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Twenty-six rabbits were exposed to a pure tone of 2kHz, 100dB for 2 hours, and were devided into five groups. Group I: immediately decapitated after acoustic exposure. Group II: decapitated 3 days after. Group III: decapitated 7 days after. Group IV: decapitated 14 days after. Group V: decapitated 30 days after. Five rabbits were used as control. The timedepending changes of the infranuclear regions of the outer hair cells of these animals were observed with an electron microscope. As the results the outer hair cells were classified, according to the histological findings, into the following groups. Normal cells, enhanced cells (small vesicles and free ribosomes were increased in number and the electron density of the matrix became higher) and reduced cells (small vesicles and free ribosomes were decreased and the electron density of the matrix became lower). Normal cells were 25% in the group I, 30% in the group III, 45% in the group IV and 60% in the group V. Enhanced cells were 8% in the group I, 7% in the group III, 3% in the group IV and 4% in the group V respectively. Reduced cells were 67% in the group I, 63% in the group III, 42% in the group IV and 36% in the group V.
社団法人日本耳鼻咽喉科学会の論文