カナマイシン難聴の個体差発現機序に関する実験的研究

概要

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In order to clarify the mechanism of individual variation of kanamycin ototoxicity, the possible relationship between the outer hair cell damage by kanamycin and the levels of kanamycin in serum or perilymph, and renal damage were carried out in rabbits. The following results were obtained.1. Experimented animals showed considerable variations in the levels of kanamycin in serum or perilymph, and in the degrees of the outer hair cell or renal damage.2. No relationship was seen between the outer hair cell damage and renal damage.3. The degrees of the outer hair cell damage were closely correlated to the levels of kanamycin in perilymph.These findings suggest that the individual variations of the outer hair cell damage induced by kanamycin would be more closely correlated to the individual differences in the transferability of kanamycin into inner ear than to those in the vulnerability of the outer hair cells or kidneys.
社団法人日本耳鼻咽喉科学会の論文