Histogenesis and Development of Large Bowel Carcinoma (from Minute Carcinoma to Advanced Carcinoma).:from Minute Carcinoma to Advanced Carcinoma

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We examined the histogenesis and development of the large bowel carcinoma using various appearance of 422 lesions of the large bowel neoplasias within 20mm in diameter.<BR>Our results : 1.2/3 lesions of the minute carcinomas within 5 mm in diameter were accompanied no adenomatous element and thought de novo carcinomas. 2. Many lesions of polyp type early carcinomas including minute carcinomas were accompanied adenomatous element. 3. The rate of submucosal invasion in early carcinomas was higher in the superficial type than in polyp type. 4. When the superficial type early carcinomas were larger, these lesions showed both the elements of elevation and depression. 5. Almost lesions of the advanced carcinoma resembled the superficial type early carcinoma in gross appearance.<BR>Our results suspected that 2/3 route of the development of the large bowel carcinoma was correspond to the de novo carcinoma theory and 1/3 of that was the adenoma-carcinoma sequence theory.
日本大腸肛門病学会の論文