Bone metabolic disorder during steroid therapy for inflammatory bowel diseases.

概要

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Bone metabolic disorder is one of the untoward effects caused by steroid administration for inflammatory bowel diseases. During steroid therapy, we tried to assess its effects on bone metabolism by means of the microdensitometry method. Using MCI, ΔGSmin and ΣGS/D as indicators, the amout of adiministered prednisolone correlated with the degree of osteoporotic chages. Serum calcium, phosphorus, alkaline phosphatase and the N-terminal of PTH (parathormone) were also measured during the course, showing that the serum levels of calcium and phosphorus deviated in some cases where the doses of steroid were low. Administration of activated vitamin D (lα-OH-D3), 0.5 μg per day, during steroid therapy showed a tendency to prevent the development of osteoporosis and/or normalize the values already mentioned, in so far as the cumulative steroid dose was less than 4000 mg. These data indicated that, during steroid therapy, attention should be directed to its harmful effects on bone metabolism, and that the desirable effects of la-OH-D3 should be appreciated.
日本大腸肛門病学会の論文