The influence of hypogastric and sacral nerves on activity of the internal anal sphincteric muscle and anal canal resting pressure in the dog.

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Surgery on the intrapelvic organs is often followed by anorectal, bladder and sexual dysfunction due not only to the excision of the organ, but also to damage of the intrapelvic autonomic nerves. Therefore, some techniques to reduce the excision area and to preserve intrapelvic nerves as much as possible have been studied so as to retain the function of such organs. Thus, we have studied the influence of the denervation of hypogastric and sacral nerves on the anorectal function with manometric and myoelectrical recordings in the dog. The results were as follows. 1) Within five weeks after both hypogastric and sacral denervation, neither anal canal resting pressure nor electrical activity of the internal anal sphincter was significantly different from the preoperative level. 2) After denervation of both nerves, anorectal reflex was positive. Compared with the preoperative pattern of the reflex, however, the inhibition time of the internal anal sphincter motility at the reflex was more remarkably prolonged than that observed in normal dogs. 3) Rectal compliance increased one week after denervation of both nerves, but tended to return to the preoperative level at three weeks or later. 4) These findings suggest that the activity of the internal anal sphincter and the anorectal reflex are controlled mainly by the myenteric plexus, which is affected by hypogastric and sacral nerves at a higher level.
日本大腸肛門病学会の論文