<原著>局所進行乳癌に対する局所静脈の血行遮断術式を併用した術前制癌剤動注法

概要

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An important factor in the intra-arterial infusion chemotherapy is the concentration of anti-cancer agent in the cancerous tissues. The procedure of local vein blocking method comprises cutting off the local vein of lateral thoracic vein, thoracodorsal vein, thoracoacromial vein and internal thoracic vein by ligature, and then insertion of the catheter into subclavian artery and internal thoracic artery. The administration of anti-cancer agent was performed by infusing one shot of ADM 40 mg twice and 5 FU 500 mg/day for two weeks. The local vein blocking method of intra-arterial infusion chemotherapy was applied to 4 cases of locally advanced breast cancer patients, and the changes of the local findings of primary tumor and regional lymph nodes before and after the treatment of intra-arterial infusion chemotherapy were studied. The blood concentration of anti-cancer agent in the peripheral vein immediately after infusion of one shot of ADM 20 mg was 2. 71 μg/ml for control and 0.94 μg/ml for the local vein blocking group. Whereas the concentration in the cancerous tissues at 30 min. later was 2.7 μg/g for the local vein blocking group. The value was 2.8 times of the level of the control group. The local findings included the contraction or disappearance of primary tumor and regional lymph nodes, and also effective grade III according to Shimosato's classi fication histologically.
近畿大学の論文
1979-06-25