Venous invasion in colorectal cancer by immunohistochemical technique of laminin.

概要

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When laminin, a constituent of the basement membrane, was used for the judgement of venous invasion in colorectal cancers, good results were obtained.<BR>The rate of cancers positive for venous invasion was high with 77.9%. In laminin stain, veins in tissues of cancer and the capillaries were also stained distinctly. The relation between venous invasion disclosed by laminin stain and liver metastasis was examined.<BR>In the site of venous invasion the findings around the cancer were noteworthy. The number of involved veins was not related with the rate of liver metastasis. With the size of involved veins the rate of liver metastasis was high in veins below 50μm in diameter as well as in vessels above 200μm in diameter, the venules were considered to be related also well with liver metastasis.<BR>Thus, laminin stain was considered to be useful for judging venous invasion of cancers.
日本大腸肛門病学会の論文