Clinical evaluation of CEA and other tumor markers for patients with colorectal cancer.

概要

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About half of patients with colorectal cancer had a negative test for serum CEA assay. Therefore the combination assay of seven kinds of tumor markers ; CEA, CA 19-9, CA 125, ferritine, BFP, TAP and 2-microglobulin was performed in 105 patients with colorectal cancer preoperetively. The sero-positivities of CEA, C 19-9 and TAP were correlate with Dukes staging and especially these three assays had positive in over 50 % with Dukes stage D. Though the low sero-positivity compared with CEA, CA 19-9 assay was effective as a monitor following surgery. And the combination assay of CEA and CA 19-9 seems to be useful to increase the sensitivity.<BR>All tumor markers examined in this serises lack both the sensitivity and the specificity to be useful as a diagnosis of Dukes stage A.
日本大腸肛門病学会の論文