Effect of ulinastatin on respiratory functions after pulmonary resection.

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We performed a randamized study of the effect of ulinastatin on the blood level of granulocytic elastase and on respiratory function after pulmonary resection for lung cancer. Twenty eight consecutive patients who underwent pulmonamy resection for lung cancer were classified into two groups, 13 patients were administered ulinastatin 100, 000 units intravenously just before thoracotomy, followed by a continuous drip infusion of 200, 000 units during surgery and 200, 000 units per day from day 1 to day 4. The other 15 patients were not treated with the agent (control group). To determine the effectiveness of ulinastatin, we examined the following parameters. The serum granulocytic elastase level was measured and blood gas analysis was performed on the day before operation and on postoperative days 1, 3, and 7. The serum level of granulocytic elastase was increased in both groups on postoperative days 1 and 3. A-aD02 and the respiratory index (A-aDO<SUB>2</SUB>/PaO<SUB>2</SUB>) were significantly lower on day 1 in the ulinastatin group than in the control group. We conclude that ulinastatin maintains respiratory function in patients with pulmonary resection for lung cancer.
特定非営利活動法人日本呼吸器外科学会の論文