Effects of Ajmaline on Non-sodium Ionic Currents in Guinea Pig Ventricular Myocytes.
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概要
- 論文の詳細を見る
The lack of currently available data stimulated us to investigate the electrophysiological effects of ajmaline, a classical class Ia antiarrhythmic agent, on various currents responsible for the action potential plateau and repolarization phases. The whole cell patch clamp recording technique was applied to guinea pig ventricular myocytes. Ajmaline suppressed the Ca2+ current (ICa) in a dosedependent manner (K∂=1.2×10-5M) without affecting the steady-state inactivation kinetics and the voltage dependency of the currentvoltage relationship. Ajmaline inhibited the inward portion of the inward rectifying K+ current (IK1). Ajmaline decreased the delayed rectifier K+ current (IK) without altering the activation or deactivation time courses. All these inhibitory effects of ajmaline prolonged the action potential duration in a dose dependent manner. The inhibitory actions of ajmaline on the action potential upstroke and various currents responsible for the plateau and repolarization may contribute to the observed suppression of depolarizationinduced abnormal automaticities by this agent.
- International Heart Journal刊行会の論文
著者
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FUJINO Takehiko
Institute of Health Science, Kyushu University
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Kanaya Shozo
Institute Of Health Science Kyushu University
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Maruyama Toru
The First Department of Medicine, Kyushu University
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Kaji Yoshikazu
The First Department Of Internal Medicine Faculty Of Medicine Kyusyu University
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TSUDA YASUO
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Niho Yoshiyuki
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Fujino Takehiko
Institute For The Rhelogical Functions Of Foods
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Tsuda Yasuo
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Enomoto Katsuaki
The First Departrnent Of Internal Medicine Kyushu University Fukuoka
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NIHO Yoshiyuki
The First Department of internal Medicine, Faculty of Medicine, Kyushu University
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Imoto Masahiro
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Nagashima Ryuichi
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Kaneko Takeo
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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KAJI Yoshikazu
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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