Coronary Dilating Effects of Intracoronary Nicorandil. Comparison with Isosorbide Dinitrate.

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概要

• 論文の詳細を見る

• Although nicorandil, N-(2-hydroxyethyl) nicotinamide dinitrate, is a nitrate ester, its cardiovascular action differs from that of nitrate compounds in several aspects. In this quantitative angiographic study, the acute coronary dilating effect of intracoronary nicorandil (0.25, 0.50, 1.0mg) was compared with that of isosorbide dinitrate (ISDN; 1.0mg) in 46 patients with or without ischemic heart disease (IHD). Dosedependent right coronary dilating action was observed by intracoronary administration of nicorandil without any adverse effects. The same degree of right coronary dilation was achieved by the intracoronary application of equivalent doses of ISDN. We conclude that intracoronary administration of nicorandil is beneficial for the supportive treatment of IHD during coronary artery investigation and intervention without the risk of severe systemic hypotension.

• International Heart Journal刊行会の論文

著者

• Maruyama Toru

  The First Department of Medicine, Kyushu University

• Kaji Yoshikazu

  The First Department Of Internal Medicine Faculty Of Medicine Kyusyu University

• Niho Yoshiyuki

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Kanaya Shozo

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Fujino Takehiko

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Tsuda Yasuo

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• EJIMA Jun-ichi

  The First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• KANEDA Koji

  Fukuoka Higashi National Hospital

• MORIYAMA Hidetoshi

  Fukuoka Higashi National Hospital

• OHMURA Ichiro

  Fukuoka Higashi National Hospital

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