Successful Treatment of Primary Amyloidosis with Dimethylsulfoxide and Cytoreductive Chemotherapy.

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概要

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• A 42-year-old Japanese male was admitted to our hospital because of congestive heart failure (CHF). A diagnosis of primary amyloidosis was made on the basis of a heavy deposition of amyloid in the gastric submucosal tissue in addition to the hematological and immunological findings. Intermittent chemotherapy in combination with daily oral dimethylsulfoxide (DMSO) resulted in a dramatic decrease of plasma cells in the marrow as well as a gradual improvement of CHF. With this therapy, the cardiac ejection fraction was markedly improved. This case indicates that the long-standing administration of DMSO combined with cytoreductive chemotherapy is therefore effective in treating some cases with primary amyloidosis. (Internal Medicine 31 : 544-548, 1992)

• 社団法人　日本内科学会の論文

著者

• HARADA Mine

  The First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Tsuda Yasuo

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• MURAKAWA Masahiro

  the First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• SHIBUYA Tsunefumi

  the First Department of Internal Medicine, Faculty of Medicine, Kyushu University

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• Successful Treatment of Primary Amyloidosis with Dimethylsulfoxide and Cytoreductive Chemotherapy.

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