EFFECTS OF HYDROCORTISONE ON TRANSMEMBRANE CURRENTS IN GUINEA PIG VENTRICULAR MYOCYTES : Possible Evidence for Positive Inotropism
スポンサーリンク
概要
- 論文の詳細を見る
Steroid hormones are thought to have a positive inotropic action, but the precise electrophysiological effects which underlie this positive inotropism remain unknown. The effects of hydrocortisone on the L-type calcium current (I_<Ca>) of the isolated guinea pig ventricular cells were investigated under the whole-cell voltage-clamp recording. Hydrocortisone (10^<-6> to 10^<-5> M) increased the amplitude of I_<Ca> without any changes in the voltage-dependency in I_<Ca>. This agent retarded the fast inactivation component of I_<Ca>, but not the slow component. On the other hand, hydrocortisone slightly reduced the slope conductance of inward rectifying potassium current (I_<K1>) at potentials less than -50 mV. This effect on I_<K1> is favorable for the activation of I_<Ca>. Thus, these results indicate that the positive inotropism of hydrocortisone is mediated, at least in part, by a direct potentiating effect on I_<Ca>.
- 社団法人日本循環器学会の論文
- 1994-10-20
著者
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Kaji Yoshikazu
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Kaji Yoshikazu
九州大学 医学研究院病態修復内科学
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Kaji Yoshikazu
Department Of Medicine And Biosystemic Science Kyushu University
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Kanaya Shozo
Institute Of Health Science Kyushu University
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Kanaya Shozo
The First Dept. Of Intern Med. Faculty Of Medicine Kyushu University Fukuoka
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Kaji Yoshikazu
The First Department of Medicine, Kyushu University
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Fujino Takehiko
The First Department of Medicine, Kyushu University
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Niho Yoshiyuki
The First Department of Medicine, Kyushu University
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Kanda Yoshinobu
Department Of Cell Therapy And Transplantation Medicine University Of Tokyo Hospital
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Fujino T
Institute Of Rheological Function Of Foods Co Ltd
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Niho Y
Kyushu Univ. Graduate School Of Medical Sci. Fukuoka City Jpn
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Niho Y
First Department Of Internal Medicine Chihaya Hospital
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Kaji Yoshikazu
The First Department Of Internal Medicine Faculty Of Medicine Kyusyu University
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YANO KAZUTOSHI
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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TSUDA YASUO
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Fujino Takehiko
The Institute Of Rheological Functions Of Food Co. Ltd.
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Niho Yoshiyuki
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Kaji Yoshikazu
First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Kanaya Shozo
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Fujino Takehiko
Department Of Physiology Nippon Medical School Tokyo
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Fujino Takehiko
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Yano Kazutoshi
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Tsuda Yasuo
The First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Kanaya Syozo
Institute Of Health Science Kyushu University
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Kikushige Yoshikane
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Fujino Takehiko
First Dept Of Internal Medicine Kyushu University
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