Isoproterenol-induced Creatine Kinase Leakage in Langendorff-perfused Rat Heart Associated with Significant Myocardial Edema.

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概要

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• Since the mechanism of creatine kinase (CK) leakage induced by β-adrenoceptor activation remains unclear, we studied the effects of incremental application (10-9 to 104M) of isoproterenol (ISP) on the CK efflux from Langendorff-perfused isolated rat hearts under aerobic conditions. Tissue water content was estimated after the perfusion experiment. ISP-induced dose-dependent CK leakage was noted in a sigmoidal fashion, which showed low temperature-dependency (Q10 of 2.41), sensitivity to cepharantine (10-6M) and propranolol (10-7 to 10-6M) without any signs of demand ischemia or oxidant stress. CK liberation was not replicated at all by maneuvers activating cAMP-dependent protein kinase (A-kinase). Myocardial edema noted in the control ISP application was ameliorated by exposure to 10-6M propranolol or cepharantine (i. e., significant fall in tissue water content; p<0.05). Histological study revealed nonspecific myocardial fiber swelling and separation without any myocyte necrosis for all the perfusion groups. These results suggest that ISP-induced CK leakage in this model is not mediated by β-adrenoceptor stimulation, subsequent A-kinase activation or related demand ischemia, but is attributed most to the direct effects of ISP augmenting sarcolemmal CK and water permeability.

• International Heart Journal刊行会の論文

著者

• Odashiro Keita

  First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Maruyama Toru

  First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Odashiro Keita

  First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Niho Yoshiyuki

  First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Fujino Takehiko

  The Institute Of Rheological Functions Of Food Co. Ltd.

• Kaji Yoshikazu

  First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• HIRAMATSU Shin-ichi

  First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• KANAYA Shozo

  The Institute of Health Science, Kyushu University

• FUJINO Takehiko

  The Institute of Health Science, Kyushu University

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