Possible Evidence for Transmembrane K+-H+ Exchange System inGuinea Pig Myocardium.
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to obtain evidence for a transmembrane K<SUP>+</SUP>-H<SUP>+</SUP> exchange system in Langendorff-perfused whole hearts and isolated ventricular myocytes of guinea pig. Effluent relation between K<SUP>+</SUP> and pH in the whole hearts perfused with HEPES-buffered Tyrode's solution indicated a significant (p<0.05) functional coupling of K<SUP>+</SUP> uptake and H<SUP>+</SUP> extrusion that was energy-dependent and omeprazole (OPZ)-sensitive. Administration of OPZ (0.3mM) or dimethylamiloride (0.1mM), an inhibitor of Na<SUP>+</SUP>-H<SUP>+</SUP> antiport, to whole hearts subjected to the repetitive NH<SUB>4</SUB>Cl applications implied that both Na<SUP>+</SUP>-H<SUP>+</SUP> and putative K<SUP>+</SUP>-H<SUP>+</SUP> countertransports contribute to the regulation of intracellular pH. In isolated myocytes, voltage-dependent L-type Ca current (I<SUB>Ca</SUB>) was inhibited by OPZ (0.3mM) under K<SUP>+</SUP>- and Na<SUP>+</SUP>-free condition by 11 to 14%, and was inhibited to a greater extent (i.e., by 36 to 40%) by this agent in the presence of K<SUP>+</SUP>. OPZ-induced inhibition of the putative K<SUP>+</SUP>-H<SUP>+</SUP> exchanger likely resulted in subsarcolemmal acidification which was responsible for the rate-independent suppression of I<SUB>Ca</SUB>. In conclusion, these data provide functional evidence for a myocardial transmembrane K<SUP>+</SUP>-H<SUP>+</SUP> exchanger.
- International Heart Journal刊行会の論文
著者
-
Kanaya Shozo
Institute Of Health Science Kyushu University
-
Maruyama Toru
First Department of Internal Medicine, Faculty of Medicine, Kyushu University
-
Niho Yoshiyuki
First Department Of Internal Medicine Faculty Of Medicine Kyushu University
-
Fujino Takehiko
Institute For The Rhelogical Functions Of Foods
-
Nagashima Ryuichi
First Department Of Internal Medicine Faculty Of Medicine Kyushu University
-
TSUDA Yasuo
Department of Medicine, Fukuoka Teishin Hospital, Fukuoka, Japan
関連論文
- Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura With an IgG-Type Inhibitor to von Willebrand Factor-Cleaving Protease Activity
- An NcoI polymorphism in the human complement component 7 (C7) gene
- Gastrointestinal angiodysplasia in congenital platelet dysfunction
- A sequence analysis of von Willebrand factor mRNA, gene, and pseudogene in two patients with von Willebrand disease type 2B, and an investigation of gene conversion in its gene
- Effects of granulocyte colony-stimulating factor on the hemostatic system in healthy volunteers
- Primary Chronic Myelofibrosis: Clinical and Prognostic Evaluation in 336 Japanese Patients
- Interferon-α treatment of acute lymphoblastic leukemia relapse after unrelated bone marrow transplantation
- Granulocyte colony-stimulating factor-combined marrow-ablative chemotherapy and autologous blood cell transplantation for the treatment of patients with acute myelogenous leukemia in first remission
- Impaired Erythrocyte Filterability of Spontaneously Hypertensive Rats : Investigation by Nickel Mesh Filtration Technique
- P025 LOSS OF 1/f FLUCTUATION OF R-R INTERVALS IMMEDIATELY BEFORE SUDDEN DEATH
- P020 IMBALANCE OF AUTONOMIC NERVOUS SYSTEM TRIGGERS THE ARRHYTHMIAS IN ACUTE PHASE OF MYOCARDIAL INFARCTION
- P632 Effect of water temperature on circulatory and autonomic nervous response during water immersion
- -P614- THE INVESTIGATION OF POSSIBLE ACUTE CARDIOTOXICITY INDUCED BY INTERFERON-α(IFNα)(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- EFFECT OF AGE AND PHYSICAL TRAINING ON CARDIOVASCULAR RESPONSE TO MENTAL STRESS
- ヒト骨髄長期培養における造血幹細胞の増殖と分化
- A Patient with hemoglobin variant (Hb J_) unexpectedly detected by HPLC for glycated hemoglobin (Hb A_)
- Long-term Results of a Multicenter Randomized, Comparative Trial of Modified CHOP versus THP-COP versus THP-COPE Regimens in Elderly Patients with Non-Hodgkin's Lymphoma
- In Vitro Study of Deoxymethylspergualin on Functions of Lymphocytes and Bone Marrow Cells From Healthy Volunteers
- Effects of Ultrasound Energy Application on Cardiac Performance in Open-Chest Guinea Pigs : An In Vivo Pilot Study
- SIII-1 Weight Control by New Modulation Program of Eating Behabiour (BOOCS): Correlation between Mental Fatigue and Initial Decrease of Weight (Proceedings of the 49th Meeting of Japan Society of Physiological Anthropology)
- Influence of Right Atrial Structure on Outcome of Radiofrequency Catheter Ablation for Common Atrial Flutter
- Echocardiographic Observation before and after Rupture of an Aneurysm of the Sinus of Valsalva associated with Ventricular Septal Defect
- Heart Rate Variability Analysis of Patients With Idiopathic Left Ventricular Outflow Tract Tachycardia : Role of Triggered Activity
- B-P10 The Study on the cabin pressure and the Pathophysiological Changes in the Air Travelers on Board in the Domestic Commercial Aircraft. (4th. Report) (Proceedings of the 40th Meeting of Japan Society of Physiological Anthropology)
- II-3 The Study on the Pathophysiological Changes in the Air Travelers on Board in the Domestic Commercial Aircraft. (2nd. Report) (Proceedings of the 38th Meeting of Japan Society of Physiological Anthropology)
- P545 ATRIAL SYSTOLIC DYSFUNCTION AS A CAUSE OF PROGRESSION FROM PAROXYSMAL TO CHRONIC ATRIAL FIBRILLATION IN PATIENTS WITH HYPERTENSION : A CASE CONTROL STUDY
- Hypercoagulable State Following Transfusions of Granulocytes Obtained From Granulocyte Colony-Stimulating Factor-Stimulated Donors
- Interleukin-10 inhibits the autocrine growth of leukemic blast cells from patients with acute myeloblastic leukemia
- -1164- THE MEANINGS OF LEFT VENTRICULAR VOLTAGE : COMPARISON AMONG THE RACES AND WITH ECHOCARDIOGRAPHIC PARAMETERS AND HEART RATE VARIABILITY(XINJIANG UYGUR SURVEY)(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- EFFECTS OF HYDROCORTISONE ON TRANSMEMBRANE CURRENTS IN GUINEA PIG VENTRICULAR MYOCYTES : Possible Evidence for Positive Inotropism
- A novel nonsense mutation at Glu-631 in a Spanish family with complement component 7 deficiency
- Propylthiouracil-Induced severe hepatitis: A case report and review of the literature
- Loss of diurnal variation in ornithine decarboxylase and apoptosis in small intestine of Mongolian gerbils
- Down-Regulation of Human Telomeric Protein TRF1 Gene Expression During Myeloid Differentiation in Human Hematopoietic Cells
- Allogeneic peripheral blood stem cell transplantation for treatment of induction failure in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia
- Association of HLA-DRB1 0803 and 1602 with the susceptibility to primary biliary cirrhosis
- Usefulness of Questions from Patients and Their Families in Medication Guidance : Role of the Pharmacist in Integrated Therapy for Blood Cancer
- I-11 Effects of the menstrual cycles on metabolic response to prolonged aerobic exercise
- -380-EFFECT OF ADRENERGIC BLOCKADE ON HEMODYNAMIC AND METABOLIC RESPONSE TO MODERATE EXERCISE : Cardiovascular Drugs : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- SIV-2 Eating Habits in Women during Breast-Feeding and its Back Ground (2^ Report): Correlation between Eating Habits and Mental Fatigue (Proceedings of the 49th Meeting of Japan Society of Physiological Anthropology)
- SIV-1 Eating Habits in Women during Breast-Feeding and its Back Ground (1^ Report): Survey of Eating Habits by Questionnaire (Proceedings of the 49th Meeting of Japan Society of Physiological Anthropology)
- Harmony in Men and Harmony in Women
- Simultaneous Preparation of Purified Plasmalogens and Sphingomyelin in Human Erythrocytes with Phospholipase A_1 from Aspergillus orizae
- Ocular Injury Caused by an Air Bag for a Driver Wearing Eyeglasses
- Optic Nerve Changes in Ascorbic Acid-deficient Rats
- Left Ventricular Function in Patients with Stable Systemic Lupus Erythematosus
- Effects of Ajmaline on Non-sodium Ionic Currents in Guinea Pig Ventricular Myocytes.
- Thrombotic Obstruction of the Right Coronary Artery in a Postoperative Patient with Bland-White-Garland Syndrome.
- Experimental Ablation Study Using a New Long Linear Probe in Isolated Porcine Hearts.
- Effects of Increased Physical Activity and Mild Calorie Restriction on Heart Rate Variability in Obese Women.
- Isoproterenol-induced Creatine Kinase Leakage in Langendorff-perfused Rat Heart Associated with Significant Myocardial Edema.
- Diffuse endocardial thrombus in left ventricle associated with a case of hypereosinophilic syndrome.
- Notched T Wave as Evidence of Autonomic Nervous Lability in Duchenne Progressive Muscular Dystrophy.
- Possible Evidence for Transmembrane K+-H+ Exchange System inGuinea Pig Myocardium.
- A 17-Year Follow-Up Study of Hypertensive and Normotensive Male University Students in Japan
- Verapamil Prevents Impairment in Filterability of Human Erythrocytes Exposed to Oxidative Stress
- Usefulness of Questions from Patients and Their Families in Medication Guidance : Role of the Pharmacist in Integrated Therapy for Blood Cancer