Calcium Concentration during Anoxic Perfusion Modifies Post-ischemic Hypercontraction in the Canine Heart.
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概要
- 論文の詳細を見る
The purpose of this study was to clarify the role of calcium flux in the pathogenesis of transient overshoot in regional myocardial contractile function after brief ischemia (post-ischemic hypercontraction). Six open-chest anesthetized dogs were examined. The left anterior descending coronary artery (LAD) was cannulated with a bypass system from the left carotid artery. Two minutes of total coronary occlusion of the LAD resulted in a post-ischemic hypercontraction 1 minute after reperfusion. Post-ischemic hypercontraction was abolished after reperfusion following 2 minutes of perfusion with anoxic Krebs-Henseleit solution containing 2.5mM calcium. Post-ischemic hypercontraction occurred after calcium-free anoxic perfusion. The regional myocardial contractile function remained depressed 1 minute after reperfusion following anoxic perfusion with 5.0mM calcium solution. Thus, post-ischemic hypercontraction was modified by the calcium concentration during anoxia. Alteration in transsarcolemmal calcium influx during reperfusion, which was modified by alterations in the calcium environment during anoxia, could be responsible for this phenomenon.
- International Heart Journal刊行会の論文
著者
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Yoshikawa Tsutomu
Cardio-pulmonary Division of Keio University School of Medicine
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Nakamura Yoshiro
Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine
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Ikeda Fumihiko
Cardiopulmonary Division Department Of Medicine Keio University
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Akaishi Makoto
Cardio-pulmonary Division Dept. Of Internal Medicine School Of Medicine Keio University
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Handa Shunnosuke
Cardio-pulmonary Division Dept. Of Internal Medicine School Of Medicine Keio University
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Akaishi Makoto
Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University
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IKEGAWA Toru
Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University
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YOSHIKAWA Tsutomu
Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University
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