Myocardial Uptake of Iodine-125-labeled 15-(P-Iodophenyl)-3-(R, S)-Methyl Pentadecanoic Acid is Decreased in Chronic Diabetic Rats With Changes in Subcellular Distribution
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概要
- 論文の詳細を見る
Iodine-123-labeled 15-(p-iodophenyl)-3-(R, S)-methyl pentadecanoic acid(^<123>I-BMIPP)is widely used to detect myocardial metabolic changes, but the preferred energy substrates in the myocardium would be expected to be altered in the presence of metabolic disorders such as diabetes mellitus(DM).We investigated the metabolism of branched-chain fatty acids in the myocardium of rats with DM.Streptozotocin-induced DM rats were examined 48 h(acute;AD)and 6 weeks(chronic;CD)after injection of streptozotocin.Hearts were excised 15 min or 60 min after injection of 0.185 MBq of ^<125>I-BMIPP, followed by homogenization in an EDTA-Tris buffer.The homogenates were subjected to differential centrifugation to obtain the mitochondrial(MF)and cytoplasmic(CF)fractions.Myocardial ^<125>I uptake tended to increase in the AD group, but the change was not significant.Myocardial ^<125>I uptake at 15 min was significantly lower in the CD group than in the control ggroup, even in the insulin-treated rats[control(CC), 4.4±0.4;not treated(CDN), 3.3±0.5;insulin-treated(CDI), 3.4±0.4×10^4 cpm/g, p<0.05 in each case].The ^<125>I count value corrected for the blood count(counts/min(cpm)per g of protein divided by blood cpm)in the MF decreased by 40% at 60 min in the CC group, but increased by 60% in the CDN group.The results of the present study suggest that the myocardial uptake of branched-chain fatty acids in decreased in rats with chronic diabetes, probably as a result of mitochondrial dysfunction.
- 社団法人日本循環器学会の論文
- 1998-04-20
著者
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Shinmura Ken
Department Of Geriatric Medicine Keio University School Of Medicine
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Hasegawa Hiroshi
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Tani Masato
Department Of Geriatric Medicine Keio University School Of Medicine
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Tani Masato
Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University
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Hasegawa Hiroshi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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NAKAMURA Yoshiro
Department of Chemistry, Faculty of Science, Konan University
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Nakamura Yoshiro
Geriatrics, School of Medicine, Keio University
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Nakamura Y
Geriatrics School Of Medicine Keio University
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Nishikawa Yasuhiro
Cardiopulmonary Division Dept. Of Med. School Of Med. Keio Univ.
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Nakamura Yoshiro
Department Of Internal Medicine School Of Medicine Keio University
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Suganuma Yukako
Department of Geriatric Medicine, Keio University School of Medicine
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Hayashi Yoko
Department of Geriatric Medicine, Keio University School of Medicine
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Xing-dong Guo
Department of Geriatric Medicine, Keio University School of Medicine
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Nakamura Yoshiro
Dept. Of Intern. Med. Keio Univ. School Of Med.
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Tani Masato
Department Of Cardiology
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Tani Masato
Cardio-pulmonary Division School Of Medicine Keio University
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Nakamura Yoshiro
Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine
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Nakamura Yoshiro
Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University
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Nakamura Yoshiro
Department Of Internal Medicine Keio University Hoipital
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Xing-dong Guo
Department Of Geriatric Medicine Keio University School Of Medicine
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Nishikawa Yasuhiro
Department Of Internal Medicine School Of Medicine Keio University
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Nakamura Yoshirou
Cardiopulmonary Division School Of Medicine Keio Univ.
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Suganuma Yukako
Department Of Geriatric Medicine Keio University School Of Medicine
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Nishikawa Yasuhiro
Cardiopulmonary Division Department Of Medicine Keio University School Of Medicine
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Hayashi Yoko
Department Of Geriatric Medicine Keio University School Of Medicine
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Nakamura Yoshiro
Department Of Chemistry Faculty Of Science Konan University
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Hayashi Yoko
Department Of Biochemistry And Molecular Biology Nippon Medical School
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Nakamura Yoshiro
Cardiopulmonary Division. Department Of Internal Medicine Keio University
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Hasegawa Hiroshi
Department Of Geriatric Medicine Keio University School Of Medicine
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Hasegawa Hiroshi
Department Of Applied Physics Department Of Physics University Of Tokyo
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Nakamura Yoshirou
Cardiopulmonary Division. Department Of Internal Medicine Keio University
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Hasegawa Hiroshi
Department Of Adme And Toxicology For Screening Developmental Research Laboratories Shionogi & Co. Ltd.
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