Effect of Stepwise Normalization of Perfusate pH on Post-Ischemic Functional Recovery and Ca^<2+> Overload in Isolated Rat Hearts

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概要

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• The purpose of this study was to examine whether initial acidic reperfusion after ischemia followed by stepwise normalization of perfusate pH could improve functional recovery and to assess whether this is associated with a reduction in Ca^<2+> overload. Isolated rat hearts were subjected to global ischemia for 25 min, followed by 30 min of reperfusion. In the control group (Group C), the perfusate pH was 7.4 throughout reperfusion. In the acidic groups, the perfusate pH was 6.8 for the first 5 min, 7.1 for the second 5 min, and 7.4 for the remainder of reperfusion. Acidic buffer was produced either by adding HCl (metabolic acidosis, Group MA) or by bubbling with gas containing 12 to 24% CO_2 (respiratory acidosis, Group RA). The recovery of ventricular function, Ca^<2+> uptake, and energy metabolites were analyzed. Thirteen of the 15 hearts in Group C, 14 of the 15 in MA and 8 of the 15 in RA recovered regular cardiac rhythm at the end of reperfusion. In these hearts which exhibited normal rhythm, the percent recovery in developed pressure was higher (MA: 73±8, RA: 68±6, C: 51±5%, p<0.05) and left ventricular end-diastolic pressure was lower (MA: 5.1±1.4, RA: 5.9±1.3, C: 14.2±2.7 mmHg, p<0.05) in the acidic groups. The improved recovery was associated with a significant reduction in Ca^<2+> uptake which persisted with the restoration of normal pH. These results demonstrate that early acidic reperfusion enhances contractile recovery and diminishes Ca^<2+> overload. Moreover, these salutary effects are maintained after stepwise normalization of the perfusate pH to physiological values.

• 社団法人日本循環器学会の論文
• 1996-08-20

著者

• Shinmura Ken

  Department Of Geriatric Medicine Keio University School Of Medicine

• Tani Masato

  Department Of Geriatric Medicine Keio University School Of Medicine

• Tani Masato

  Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University

• Asakura Yasushi

  Department of Caridology, Toyohashi Heart Center

• Asakura Yasushi

  Department Of Caridology Toyohashi Heart Center

• Asakura Yasushi

  Department Of Cardiology Toyohashi Heart Center

• Asakura Yasushi

  Cardiopulmonary Division Department Of Medicine Keio University School Of Medicine

• NAKAMURA Yoshiro

  Department of Chemistry, Faculty of Science, Konan University

• Nakamura Yoshiro

  Geriatrics, School of Medicine, Keio University

• Nakamura Y

  Geriatrics School Of Medicine Keio University

• Nishikawa Yasuhiro

  Cardiopulmonary Division Dept. Of Med. School Of Med. Keio Univ.

• Nakamura Yoshiro

  Department Of Internal Medicine School Of Medicine Keio University

• Ebihara Yoshinori

  Departments of Geriatric Medicine, Keio University School of Medicine

• Nakamura Yoshiro

  Dept. Of Intern. Med. Keio Univ. School Of Med.

• Tani Masato

  Department Of Cardiology

• Tani Masato

  Cardio-pulmonary Division School Of Medicine Keio University

• Nakamura Yoshiro

  Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine

• Nakamura Yoshiro

  Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University

• Nakamura Yoshiro

  Department Of Internal Medicine Keio University Hoipital

• Asakura Yasushi

  Cardiopulmonary Division Keio University School Of Medicine

• Nishikawa Yasuhiro

  Department Of Internal Medicine School Of Medicine Keio University

• Nakamura Yoshirou

  Cardiopulmonary Division School Of Medicine Keio Univ.

• Ebihara Yoshinori

  Departments Of Geriatric Medicine Keio University School Of Medicine

• Nishikawa Yasuhiro

  Cardiopulmonary Division Department Of Medicine Keio University School Of Medicine

• Nakamura Yoshiro

  Department Of Chemistry Faculty Of Science Konan University

• Nakamura Yoshiro

  Cardiopulmonary Division. Department Of Internal Medicine Keio University

• Nakamura Yoshirou

  Cardiopulmonary Division. Department Of Internal Medicine Keio University

• EBIHARA Yoshinori

  Department of Geriatric Medicine, Keio University School of Medicine

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