Effect of E4031, a Class III Antiarrhythmic Drug, on Ischemia- and Reperfusion-induced Arrhythmias in Isolated Rat Hearts.
スポンサーリンク
概要
- 論文の詳細を見る
The delayed outward rectifier K+ channel has a role in the increase in automaticity of myocytes under pathophysiological conditions. The purpose of the present study was to clarify the effect of blockade of outward recitifier K+ channels by a class III antiarrhythmic drug, E4031, on ischemia- and reperfusion-induced arrhythmias. Ion fluxes, energy metabolites and cardiac function were measured and the epicardial electrocardiograms of Langendorffperfused rat hearts were recorded during initial perfusion, global or regional ischemia and reperfusion. 10-7M of E4031 administered during the initial perfusion did not prolong the QT interval, but slowed the heart rate (Control: 222, E4031: 183bpm, p<0.05), increased myocardial 45Ca2+ uptake (Control: 2.1, E4031: 2.9μmol/g dwt, p<0.05) and attenuated the loss of intracellular K+ during ischemia (Control: 238, E4031: 248μmol/g dwt, p<0.05). E4031 tended to reduce ischemia-induced ventricular tachyarrhythmias (Control: 60, E4031: 30%, n. s.), but reperfusion-induced ventricular tachyarrhythmias were sustained longer by the administration of E4031 (Control: 255, E4031: 623sec, p<0.05). Prior exposure to E4031 decreased the depletion of high energy phosphates during ischemia, but suppressed their recovery during reperfusion. These results suggest that the attenuated loss of K+ from the ischemic myocardium and the decrease in heart rate by E4031 contributed to the reduction of ischemia-induced arrhythmias. However, the increase in myocardial Ca2+ uptake and altered energy metabolism may be responsible for the increase in reperfusion-induced arrhythmias.(Jpn HeartJ 1998; 39: 183-197)
- International Heart Journal刊行会の論文
著者
-
Shinmura Ken
Department Of Geriatric Medicine Keio University School Of Medicine
-
Tani Masato
Department Of Cardiology
-
Ebihara Yoshinori
Departments Of Geriatric Medicine Keio University School Of Medicine
-
Nakamura Yoshiro
Department Of Chemistry Faculty Of Science Konan University
-
Hasegawa Hiroshi
Department Of Adme And Toxicology For Screening Developmental Research Laboratories Shionogi & Co. Ltd.
-
Shinmura Ken
Department of Geriatric Medicine, Keio University School of Medicine
-
EBIHARA Yoshinori
Department of Geriatric Medicine, Keio University School of Medicine
関連論文
- Influence of cooling jacket and drinking water on body temperature regulation during exercise in persons with spinal cord injury
- OJ-256 Erythropoietin Prevents Apoptotic Cell Death Through Erythropoietin Receptor-mediated Cytoprotective Signaling Pathways(Growth factor/Cytokine-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-056 Erythropoietin Prevents LV Remodeling after Myocardial Infarction through Erythropoietin Receptor-Induced Signaling Pathways in the Heart(Acute myocardial infarction, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-242 Erythropoietin Has an Ischemic Postconditioning-like Effect on Myocardium through a Direct Action on Cardiomyocytes(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeti
- Cardioprotective Effects of Granulocyte Colony-stimulating Factor in Chronic Hibernating Swine Myocardium(Old Myocardial Infarction/Remodeling 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Beneficial Effects of G-CSF on Coronary Atherosclerotic Lesion in Watanabe Heritable Hyperlipidemic Rabbits(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Direct Effects of G-CSF on Cardioprotection against Ischemia/Reperfusion Injury(Myocardial Ischemia-reperfusion, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PPARgamma Ligand Inhibits the Progression of Inflammation in Myosin-induced Autoimmune Myocarditis in Rats (Myocarditis, Basic/Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-482 G-CSF Prevents Cardiac Remodeling after Acute Myocardial Infarction in Swine(Old Myocardial Infarction/Remodeling 1 (IHD) : OJ59)(Oral Presentation (Japanese))
- Amelioration of Hypertensive Heart Failure by Amlodipine May Occur via Antioxidative Effects
- A Higher Order Generalization of an Alias-Free Discrete Time-Frequency Analysis(Special Section on Digital Signal Processing)
- A Note on Constrained Least Squares Design of M-D FIR Filter Based on Convex Projection Techniques(Special Section on Digital Signal Processing)
- CONSTRAINED LEAST SQUARES DESIGN OF M-D FIR FILTER BASED ON CONVEX PROJECTION TECHNIQUES
- OJ-243 Role of c-Src Tyrosine Kinase in Ischemic Myocardium(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-769 Glucocorticoid Protects Heart from Ischemia-reperfusion Injury through Activation of Lipocalin-type Prostaglandin D Synthasederived PGD2 Biosynthesis(PJ129,Myocardial Ischemia-reperfusion (Basic, Clinical) (IHD),Poster Session (Japanese),The 73rd A
- Noninvasive Detection of Cardiac Repair After Acute Myocardial Infarction in Rats by 111In Fab Fragment of Monoclonal Antibody Specific for Tenascin-C
- Noninvasive Detection of Experimental Autoimmune Myocarditis in Rats by [In-111]-Anti-Tenascin-C Antibody and SPECT
- Facile Synthesis of Optically Active α-Methyl-α-amino Acids
- -0196-EVALUATION OF TRICUSPID REGURGITATION BY VENA CAVAL FLOW PATTERN USING A CATHETER-TIP DOPPLER VELOCIMETER
- OJ-446 Cerivastatin inhibits the development of heart failure by reducing cardiac apoptosis and cytokine expression in Dahl rat heart failure model(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
- OE-105 Granulocyte-colony stimulating factor prevents transition from left ventricular hypertrophy to diastolic heart failure in hypertensive rats(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
- Effects of Torasemide on Heart Failure
- SUPRAVALVULAR AORTIC STENOSIS ASSSOCIATED WITHAORTIC ANEURYSM
- Clinical and Experimental Studies on Pulmonary and Coronary Circulation : PROCEEDINGS OF THE 25TH ANNUAL MEETING JAPANESE CIRCULATION SOCIETY (Part II)
- Myocardial Uptake of Iodine-125-labeled 15-(P-Iodophenyl)-3-(R, S)-Methyl Pentadecanoic Acid is Decreased in Chronic Diabetic Rats With Changes in Subcellular Distribution
- Effects of α_1-Adrenoreceptor Subtype Blockade on Ischemia-Reperfusion Injury
- Effect of Stepwise Normalization of Perfusate pH on Post-Ischemic Functional Recovery and Ca^ Overload in Isolated Rat Hearts
- -0951- Effect of Methylisobutylamiloride, an Na/H Exchange Inhibitor, on Reperfusion Ventricular Tachyarrhythmias in Ischemic Rat Hearts(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- ATTENUATION OF MYOCARDIAL STUNNING BY AN INCREASE IN THE H^+ BUFFERING CAPACITY OF THE PERFUSATE AND THAT BY HYPOXIC PREPERFUSION ARE AFFIECTED DIFFERENTLY BY THE FREE[Ca^]OF THE PERFUSATE
- ST SEGMENT ELVATION IN THE NON-ISCHEMIC MYOCARDIUM IS INDUCED BY CONTRACTILE DYSFUNCTION
- OJ-091 Feasibility and Safety of G-CSF Treatment in Patients with AMI(Acute myocardial infarction, clinical (diagnosis/treatment)-3 (IHD) OJ16,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Stress-induced blood pressure elevation in subjects with mild cognitive impairment : Effects of the dual-type calcium channel blocker, cilnidipine
- White matter lesions as a feature of cognitive impairment, low vitality and other symptoms of geriatric syndrome in the elderly
- 3 Endothelial-cardiomyocyte Interactions Play Important Roles in Erythropoietin-induced Cardioprotective Effects after Myocardial Infarction(Interaction between Myocardium and Vasculature in Heart Failure-Novel Insights from Cytokine Signal Network-,Sympo
- PJ-105 Erythropoietin promotes angiogenesis through Akt/VEGF pathway in cardiomyocytes and prevents left ventricular remodeling after myocardial infarction(Growth factor/Cytokine(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Ja
- OE-267 Erythropoietin Promotes Cardiomyocytes Survival through Erythropoietin Receptor-mediated Cytoprotective Signaling Pathways and Prevents Left Ventricular Remodeling after Myocardial Infarction(Acute myocardial infarction, basic(01)(IHD),Oral Present
- 2 G-CSF Therapy for Acute Myocardial Infarction : From Animal Experiments to Clinical Trials(Symposium 12 (SY-12) (M) Clinical Experiences of Regenerative Medicine in Cardiovascular Diseases,Special Program,The 72nd Annual Scientific Meeting of the Japane
- 1 Cytokine therapy for myocardial infarction-G-CSF and erythropoietin(Plenary Session 2 (PL-2) (IHD) Myocardial Protection Strategy after Reperfusion Therapy in Acute Coronary Syndrome,Special Program,The 72nd Annual Scientific Meeting of the Japanese Cir
- PJ-154 Intracoronary Injection of G-CSF Ameliorates the Progression of Left Ventricular Remodeling after Myocardial Ischemia/reperfusion in Rabbits(Acute myocardial infarction, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- 3 Feasibility and Safety of G-CSF Treatment for Left Ventricular Dysfunction After Acute Myocardial Infarction (GLEAM) : A Randomized Controlled Trial(Clinical Trials of Regeneration Therapy in Japan, The 71st Annual Scientific Meeting of the Japanese Cir
- Intracoronary Injection of Granulocyte Colony-Stimulating Factor Ameliorates the Progression of Left Ventricular Remodeling After Myocardial Ischemia/Reperfusion in Rabbits
- PJ-439 Granulocyte Colony-stimulating Factor Ameliorates the Progression of Atherosclerosis(Acute myocardial infarction, basic-4 (IHD) PJ74,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-045 Amlodipine Prevents Hypertensive Heart Failure through Both Antioxidative and Non-antioxidative Effects in Rats : Analysis by Gene Expression Profile(Heart failure, basic-7 (M) PJ8,Poster Session (Japanese),The 70th Anniversary Annual Scientific Me
- ACE Inhibitor Prevents Hypertensive Heart Failure Through Both Antioxidative and Non-antioxidative Effects in Rats-Analysis by Gene Expression Profile (Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese C
- COMPARISON OF CKMB,MYOGLOBIN,CK ISOFORM RATIO,HUMAN HEART FATTY ACID-BINDING PROTEIN AND TROPONIN T FOR EARLY DETECTION OF CORONARY REPERFUSION
- THE PROTECTION OF THE ISCHEMIC MYOCARDIUM WITH CoQ10 : Cardiovascular Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE RELATIONSHIP BETWEEN ISCHEMIAINDUCED DECLINE OF MYOCARDIAL ATP CONTENT AND DISTURBANCE OF MYOCARDIAL SHORTENING : Coronary Circulation III : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ELECTROPHYSIOLOGICAL AND METABOLIC APPROACHES TO THE GENESIS OF MALIGNANT VENTRICULAR ARRHYTHMIAS IN ACUTE ISCHEMIA INDUCED BY GRADED CORONARY BLOOD FLOW REDUCTION : Arrhythmia II : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese
- High adiponectin concentration and its role for longevity in female centenarians
- Tokyo Centenarian Study : Aging inflammation hypothesis
- -433- CARDIOVASCULAR EFFECTS OF INTRAVENOUS AND INTRACORONARY ADMINISTRATION OF ATRIAL NATRIURETIC PEPTIDE IN HALOTHANE ANESTHETIZED DOGS
- Atomic Hydrogen Annealing of Gate Dielectric in Pentacene Organic Thin-Film Transistors
- Nasopharyngeal Malignancies Causing Abducens Palsy
- Absolute threshold of hearing decreased by perceiving a previous sound
- Previous sound effects on loudness in paired comparison experiments
- Interstimulus interval dependence of the loudness difference limen obtained by taking into account the presentation order effect
- A NEW APPROACH TO NONIVASIVE CORONARY ARTERY VISUALIZATION USING CROSS SECTIONAL ECHOCARDIOGRAPHY : Echocardiography I : IIIrd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- A CASE OF ANOMALOUS PULMONARY VENOUS DRAINAGE FROM THE ENTIRE LEFT LUNG ASSOCIATED WITH COMPLETE HEART BLOCK
- OE-008 G-CSF activates Jak/STAT signaling cascade and increases VEGF expression in cardiac myocytes(Vasoactive Compound/Growth Factor/Cytokine 1 (H) : OE2)(Oral Presentation (English))
- P642 Mismatch of Free Fatty Acid(FFA)Metabolism and Blood Flow in Various Heart Diseases : An Evaluation of Metabolism/Flow Map Derived from TICI-201 and I-123 BMIPP SPECT
- Pyogenic granuloma of the stomach successfully treated by endoscopic resection after transarterial embolization of the feeding artery
- -288-CORONARY COLLATERALS PROTECT MYOCARDIUM FROM ISCHEMIA DURING CORONARY OCCLUSION IN PTCA : Ischemic Heart Disease II : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Different gene expressions in volume overload and pressure overload hypertrophy
- Long-term antioxidant administration attenuated the progression of cardiac hypertrophy and reduced the mortality of the hypertensive heart failure rat model
- Cardioprotective genes are elevated in physiological hypertrophy
- Acute renal failure after exercise in a patient with renal hypouricemia
- THE POTENTIATED THROMBOLYSIS USING AUTOPLASMIN RICH PLASMA (APRP) UNDER SELECTIVELY BLOOD FLOW OBSTRUCTION TRANSIENTLY PRODUCED BY BALLOON-TIP CATHETER : Ischemic Heart Disease (III) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC
- Evaluation of risk of falls in patients at a memory impairment outpatient clinic
- IMPROVEMENT IN LONG-TERM PROGNOSIS BY CORONARY BYPASS SURGERY IN PATIENTS WITH 3-VESSEL CORONARY DISEASE : A Matched Case Control Study
- -0396-SIGNIFICANCE OF ERP DISPERSION AS A DETERMINANT OF INDUCIBILITY OF REENTRANT VENTRICULAR TACHYCARDIA AND ANTIARRHYTHMIC EFFECTS
- -0266-MECHANISMS OF PREVENTING VENIRICULAR TACHYARRHYTHMIAS BY PROPRANOLOL : COMPARISON WITH A SYMPATHECTOMY MODEL
- -0264-SYMPATHETIC INNERVATION OF THE ANTEROLATERAL SURFACE OF THE LEFT VENTRICLE
- -0263-EFFICACY OF ANTIARRHYTHMIC AGENTS THEIR EFFECTS ON ERP DISPERSION
- Relationship between Core Body Temperature and the Brain 5-HIAA Content in an In Vivo Microdialysis Study of Rats
- Application of Microdialysis Techniques for the Study of Exercise and Environment Physiology
- A crucial role of fibronectin in integrin and focal adhesion kinase mediated signaling in neonatal rat cardiomyocytes
- Determination of D- and L-enantiomers of methionine and [^2H_3]methionine in plasma by gas chromatography-mass spectrometry
- Gas chromatographic-mass spectrometric determination of α-ketoisocaproic acid and [^2H_7] α-ketoisocaproic acid in plasma after derivatization with N-phenyl-1, 2-phenylenediamine
- Determination of Minor and Trace Elements in Biogenic Carbonate Minerals of Coccolithophores by High-Resolution Inductively Coupled Plasma Mass Spectrometry
- -437- THE MECHANISM OF SECRETION OF ATRIAL NATRIURETIC POLYPEPTIDE : DIFFERENCE OF CARDIAC AND VOLUME OVERLOAD
- PE-067 Loss of Protection by Ischemic Preconditioning in the Ovariectomized Rat : Possible Involvement of Impaired Phosphorylation of Serine^ Residue of PKC-ε(Acute Myocardial Infarction, Basic 3 (IHD) : PE12)(Poster Session (English))
- Cyclooxygenase-2-Derived Prostacyclin is Involved in Oploid-Induced Delayed Cardioprotection in Isolated Rat Hearts
- PJ-096 Post-translational Modification of Mitochondrial Proteins with Caloric Restriction : Possible Involvement of Caloric Restrictioninduced Cardioprotection(PJ016,Molecular Biology/Genetics, Myocardium, Vascular (M),Poster Session (Japanese),The 73rd A
- OE-165 Nitric Oxide-dependent Nuclear Shuttling of Sirtl is Associated with Caloric Restriction-induced Cardioprotection(Molecular biology, myocardium (M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Strategy to Manage Pump Failure Due to Chronic Pulmonary Diseases : Pathophysiology and Treatment of Right Ventricular Overload : PANEL DISCUSSION ON PUMP FAILURE OF THE HEART WITH COMPLICATIONS : 49th Annual Scientific Session of the Japanese Circulation
- OJ-319 Adiponectin Mediates the Cardioprotective Effects of Caloric Restriction via the Activation of AMP-Activated Protein Kinase(Acute myocardial infarction, basic-2 (IHD) OJ54,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting
- Inducible Nitric Oxide Synthase Modulates Cyclooxygenase-2 Activity in the Heart of Conscious Rabbits during the Late Phase of Ischemic Preconditioning
- REGRESSION OF RIGHT VENTRICULAR HYPERTROPHY EVALUATION BY POSTOPERATIVE THALLIUM-201 MYOCARDIAL SCINTIGRAPHY : Nuclear Cardiology (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Coronary Vascular Reserve and Regional Myocardial Contractile force With Special Reference to Myocardial Metabolism
- Right Ventricular Function
- The Inhomogenous Movement of the Left Ventricle Induced by Coronary Artery Occlusion
- Changes in Pulsatile Coronary Blood Flow Induced by Coronary Vasodilators
- -1073-ENHANCEMENT OF TOXICITY TO DIGITALIS IN REPERFUSED ISCHEMIC RAT HEART : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0573-MECHANISMS OF THE PROTECTIVE EFFECTS OF THE PERFUSATE MODIFICATION IN ELECTROLYTE COMPOSITION ON REPERFUSED ISCHEMIC HEARTS
- PULMONARY EMBOLISM AND HEMOLYTIC ANEMIA IN A PATIENT WITH COLD AGGLUTININ DISEASE
- Behavior of Asynergic Ventricle
- The Changes in Pattern of Myocardial Shortening by Reduction of Regional Coronary Blood Flow
- Effect of E4031, a Class III Antiarrhythmic Drug, on Ischemia- and Reperfusion-induced Arrhythmias in Isolated Rat Hearts.
- Coronary angiography after myocardial infarction. A comparison between a Japanese community hospital and Western Countries.:A Comparison between a Japanese Community Hospital and Western Countries
- Increased Protection of the Ischemic Myocardium by Decreased Aortic Pressure.