Intracoronary Injection of Granulocyte Colony-Stimulating Factor Ameliorates the Progression of Left Ventricular Remodeling After Myocardial Ischemia/Reperfusion in Rabbits
スポンサーリンク
概要
- 論文の詳細を見る
Background Although granulocyte colony-stimulating factor (G-CSF) is known to prevent left ventricular (LV) remodeling after acute myocardial infarction (AMI), the best method of administration is unknown. Methods and Results A rabbit ischemia/reperfusion model was created and G-CSF was administered into the coronary artery immediately after reperfusion. The LV size and contraction were determined by echocardiography, and the extent of infarcted myocardium was measured by Masson-Trichrome staining. The benefits of intracoronary injection of G-CSF on LV remodeling were similar to subcutaneous injection. Conclusions Direct intracoronary G-CSF injection may become a new therapy for AMI with lower adverse effects.
- 社団法人日本循環器学会の論文
- 2006-06-20
著者
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Shiraishi Hirokazu
Department of Cardiolgy, Kyoto Prefectural University of Medicine
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Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University graduate School of Medicine
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Ueda Kazutaka
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Hasegawa Hiroshi
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Niitsuma Yuriko
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Tadokoro Hiroyuki
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Hasegawa Hiroshi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Takano H
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Takano Hiroyuki
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Ueda Kazutaka
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Toko Haruhiro
千葉大学 循環病態医科学
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夛田 浩
群馬県立心臓血管センター
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Niitsuma Yuriko
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Ueda Kazutaka
Department Of Behavioral Sciences Faculty Of Integrated Arts And Sciences Hiroshima University
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Komuro Issei
Department Of Cardiovascular Medicine Chiba University School Of Medicine
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Shiraishi Hirokazu
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Takano Hiroyuki
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Toko Haruhiro
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medecine
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Tadokoro Hiroyuki
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Hasegawa Hiroshi
Department Of Applied Physics Department Of Physics University Of Tokyo
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Takano Hiroyuki
Department Of Bio-medical Engineering Tokai University School Of High-technology For Human Welfare
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Hasegawa Hiroshi
Department Of Adme And Toxicology For Screening Developmental Research Laboratories Shionogi & Co. Ltd.
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Komuro Issei
Department Of Cardiovascular Medicine
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