Pathogenesis of Unstable Angina with 0- or 1-Vessel Disease. Important Role of Coronary Artery Spasm.:Important Role of Coronary Artery Spasm
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概要
- 論文の詳細を見る
In order to examine the possible role of coronary artery spasm in the pathogenesis of unstable angina, provocative testing for coronary spasm was performed in 43 patients with unstable angina who had 0 -or 1-vessel disease. Coronary spasm was induced in 20 (65%) of 31 patients by hyperventilation testing (ST ↑ in 18, ST ↓ in 2). Anginal attacks with either ST-segment elevation or ST-segment depression in patients without a significant organic stenosis were induced in 23 (55%) of 42 patients during treadmill exercise testing. Coronary artery spasm, showing severe (_??_90%) vasoconstriction with angina and/or ischemic electrocardiographic ST-segment deviation, was also documented angiographically in 42 (98%) of 43 patients following intracoronary injection of acetylcholine. We conclude that dynamic coronary obstruction plays an important role in the genesis of attacks in patients with unstable angina who had 0- or 1-vessel organic coronary artery disease.
著者
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Miwa Kunihisa
Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers
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Asanoi Hidetsugu
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Asanoi Hidetsugu
Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Sasayama Shigetake
Second Division Internal Medicine Toyama Medical And Pharmaceutical School
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FUJITA Masatoshi
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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MIWA Kunihisa
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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SASAYAMA Shigetake
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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