Effects of Hypoxia and Reoxygenation on Regular Contractions and Postrest Contraction in Rat Papillary Musles.

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of hypoxia and reoxygenation on regular contractions and postrest contractions (PRC) of papillary muscle of rats were studied. Isometric tension was measured during two cycles of hypoxia and reoxygenation. Trains of 80 externally continuous stimulations at 40/min were applied. PRCs were evoked by a stimulus train after a 60sec resting interval.After 90min of hypoxia (the first hypoxia period), regular contractions and PRCs decreased to 5.6±2.0% and 23.4±2.4% of baseline values, respectively (p<0.001; n=18). After 90min of reoxygenation, the recovery of the PRCs (44.4±3.4%) was better than that of the regular contractions (23.3±3.3%) (p<0.01; n=18). After 30min of hypoxia (the second hypoxic period), regular contractions and PRCs decreased to 2.2±0.6% and 13.6±1.6% of baseline values, respectively (p<0.001; n=18). However, the recovery from the second hypoxic injury was not significant for either regular contractions or PRCs. The % diastolic tension, which was normalized to the baseline for regular contractions, increased to 113.2±6.9% and 133.6±8.4% at the end of the first and the second hypoxic periods, respectively. There was statistically significant correlation between the % diastolic tension and the % hypoxic injury of PRCs (p<0.002; n=18). There was no significant relationship between % diastolic tension and % hypoxic injury of regular contractions. There was no statistically significant correlation between % diastolic tension and % recovery from the hypoxic injury of either regular contractions or PRCs.Since the PRCs are thought to be more dependent on calcium stored in the sarcoplasmic reticulum (SR) than regular contractions, SR function seems to be resistant to transient hypoxia. The marked increase in diastolic tension during repeated hypoxia may indicate SR dysfunction, leading to irreversible myocardial damage. Thus, both hypoxia and reoxygenation may regulate the recovery from hypoxic dysfunction.

• International Heart Journal刊行会の論文

著者

• Tatsumi Tetsuya

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• MIYAZAKI Hiroshi

  Second Department of Medicine,Kyoto Prefectural University of Medicine

• YAMAHARA YASUHIRO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• INOUE MIHO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Omori Itsuki

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Tatsumi Tetsuya

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural Medical College

• ASAYAMA Jun

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• INOUE Daisuke

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• MIYAZAKI Hiroshi

  Second Department of Medicine, Kyoto Prefectural University of Medicine

関連論文

• Papillary Fibroelastoma of the Aortic Valve : Evaluation with Transesophageal Echocardiography and Magnetic Resonance Imaging
• Relationship between Coronary Blood Flow Velocity Waveform and Transmural Distribution of Myocardial Blood Flow in Coronary Artery
• Human Herpes Virus 8-Negative Primary Effusion Lymphoma in a Patient With a Ventriculoperitoneal Shunt Tube
• Flow cytometric analysis of Thy-1 expression in myelodysplastic syndrome
• Flow cytometric analysis of Thy-1 expression in CD34-positive acute leukemia
• Overexpression of PRAD1/cyclin D1 in plasma cell leukemia with t(11;14)(q13;q32)
• Expression of Adhesion Molecules on Myeloma Cells
• DNA Cytofluorometry of Leukemic Cells identified by Wright-Giemsa Stain; Study on Destaining Method
• Magnetic Resonance Imaging Differentiated Partial From Complete Absence of the Left Pericardium in a Case of Leftward Displacement of the Heart
• Patients with Isolated Ventricular Noncompaction Previously Diagnosed as Dilated Cardiomyopathy
• 2D-Black Blood Magnetic Resonance Imaging Non-Invasively Detects Coronary Atherosclerosis
• Investigation of Plasma Soluble Form of Fas and Fas-Ligand in Patients with Hypertrophic Cardiomyopathy
• Elevation of Brain Natriutetic Peptide in Pericardia! Fluid in Patients with Postoperative Atrial Fibrillation Undergoing Off-Pump Coronary Artery Bypass Surgery
• Effect of local delivery of docetaxel on rabbit iliac stenosis after balloon injury
• Identification of Left Ventricular Dysfunction by gated SPECT in Angina Patients Despite Normal SPECT Images
• Plasma natriuretic peptides levels in hypertrophic cardiomyopathy with or without left ventricular cavity obliteration
• Evaluation of Atrial Contribution to Left Ventricular Filling by Myocardial Gated SPECT
• Relationship between Plasma Natriuretic Peptides Levels and Coronary Flow Reserve Evaluated by ^Tc-tetrofosmin myocardial SPECT in Patients with Hypertrophic Cardiomyopathy
• Electrocardiographic Score as a Predictor of Mortality After Subarachnoid Hemorrhage
• Assessment of Coronary Microcirculation Disturbance in Patients with Coronary Ectasia with ATP Loading Tc-99m-Tetrofosmin Myocardial SPECT
• Effectiveness of Transcatheter Mechanical Thrombus Aspiration in Patients with Acute Coronary Syndrome
• Expression and Function of CD36 on the Human Myocardium
• Increasing myocardial ^I-BMIPP uptake in non-ischemic area in a patient with acute myocardial ischemia
• Hypotension and Hypothalamic Depression Produced by Intracerebroventricular Injections of GABA in Spontaneously Hypertensive Rats : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Surgical Removal of Intra-Aortic Balloon Cathetet With Fractured Nitinol Central Lumen : A Case Report
• Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and ^Tc-tetrofosmin myocardial single photon emission computed tomography
• A patient with type I CD36 deficiency whose myocardium accumulated ^123 I-BMIPP after 4 years
• Apoptotic Myocytes Generate Monocyte Chemoattractant Protein-1 to Draw the Activated Macrophages in Ischemia-Reperfused Rat Hearts
• Aldosterone Activates Calcineurin-Dependent Mitochondrial Apoptotic Pathway in Cultured Rat Cardiac Myocytes
• Amlodipine Inhibits Doxorubicin-lnduced Apoptosis in Neonatal Rat Cardiac Myocytes : Amlodipine Releases Nitric Oxide from Cultured Rat Cardiac Myocytes
• Cardioprotective Effect of Carvedilol against Hypoxia/Reoxygenation Injury in Cultured Rat Cardiac Myocytes
• Effect of HDL on Apoptosis in Human Vascular Endothelial Cells via Caveolin and Heat Shock Protein 90 Dependent Pathway
• Effect of Quinapril on Apoptosis in Human Vascular Endothelial Cells via Bradykinin, Heat Shock Protein 90 and NOX Dependent Pathway
• Effect of Endothelin-3 on Apoptosis via Caveolin and Heat Shock Protein 90 Dependent Pathway in Human Vascular Endothelial Cells
• Effect of HDL on apoptosis in human vascular endothelial cells via caveolin and heat shock protein 90 dependent pathway
• Reverse redistribution of Tc-99m-tetrofosmin in patients with acute myocardial infarction
• COMPARISON BETWEEN ELECTROCARDIOGRAPHIC CHANGES AND THALLIUM-201 MYOCARDIAL PERFUSION IMAGES DURING TRANSIENT CORONARY OCCLUSION BY PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY : RI : 53 Annual Scientific Meeting, Japanese Circulation Society
• -P132- ASSESSMENT OF LEFT VENTRICULAR DIASTOLIC FILLING IN ISCHEMIC HEART DISEASE AFTER DIPYRIDAMOLE-LOADING : A PULSED DOPPLER ECHOCARDIOGRAPHIC STUDY
• -396- EXERCISE-INDUCED LEFT VENTRICUALR DYSFUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE (MVP)
• -194- DIFFERENT EFFECT OF POSTEXTRASYSTOLIC POTENTIATION AND CARDIAC SYMPATHETIC NERVE STIMULATION ON LEFT VENTRICULAR PERFORMANCE BEFORE AND AFTER MYOCARDIAL ISCHEMIA : Cardiac : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING
• Effect of exercise-induced activation of sympathetic nerve activity on clearance of ^I-MIBG from the myocardium
• RELATIONSHIP AMONG ABNORMALITIES OF THE ULTRASONIC THREE-LAYERED APPEARANCE OF THE VENTRICULAR SEPTUM, MYOCARDIAL FATTY ACID METABOLISM AND PERFUSION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
• THE EVALUATION OF REGIONAL MYOCARDIAL BLOOD FLOW OF THE SEPTAL WALL IN PATIENTS WITH COMPLETE LEFT BUNDLE BRANCH BLOCK
• Improved Survival of Idiopathic Dilated Cardiomyopathy in the 1990s
• MECHANISM OF CIRCULATORY COLLAPSE IN RATS WITH SPONTANEOUSLYOCCURING HYPERTRORHIC CARDIOMYOPATHY
• ANOMALOUS COURSES OF SEPTAL PERGORATORS IN PATIENTS WITH HYPERTROPIC CARDIOMYOPATHY INVESTIGATATED BY DOPPLER COLOR FLOW IMAGING
• POSTPRANDIAL EXACERBATION OF SYMPTOMS IN HYPERTROPHIC CARDIOMYOPATHY:RELATION TO CLINICAL FEATURES AND OBSTRUCTIVE GRADIENT ASSESSED BY DOPPLER ECHOCARDIOGRAPHY
• Idiopathic Long QT Syndrome With Early Afterdepolarization Induced by Epinephrine : A Case Report
• Subepicardial Aneurysm Associated With Ventricular Septal Perforation Showing a Normal Coronary Angiogram
• A Case of Cardiomyopathy Induced by Premature Ventricular Complexes
• -1120- ROLE OF NITRIC OXIDE IN IMPAIRED CORONARY CIRCULATION AND IMPROVEMENT BY ANGIOTENSIN RECEPTOR ANTAGONIST IN HYPERTENSIVE HEART(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -1045- The Role of Impaired Glucose Tolerance and Hyperinsulinemia on the Development of Hypertension in Sucrose-fed SHR(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Lowering of Blood Pressure Improves Endothelial Dysfunction by Increase of Nitric Oxide Produciton in Hypertensive Rats
• Role of the Central Nervous System in the Development of Hypertension Produced by Chronic Nitric Oxide Blockade in Rats
• P342 ROLE OF NITRIC OXIDE AND EFFECT OF L-ARGININE IN IMPAIRED CORONARY CIRCULATION OF HYPERTENSIVE HEART
• ROLE OF SYMPATHETIC NERVE INHIBITION IN THE VASODEPRESSOR EFFECT OF BROMOCRIPTINE IN NORMOTENSIVE AND HYPERTENSIVE RATS
• CENTRAL BAROREFLEX REGULATION BY THE RENAL NERVES IN ANESTHETIZED RATS
• CENTRALLY INHIBITORY EFFECT OF ADRENALLINE ON CARDIOVASCULAR AND SYMPATHETIC NERVE SYSTEM IN URETHANE ANESTHETIZED RAT
• Uncommon and dynamic changes detected by ^I-15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid myocardial single photon emission computed tomography in a stunned myocardium induced by coronary microvascular spasm
• ESTIMATION OF CORONARY FLOW RESERVE USING CORONARY FLOW VELOCITY VERSUS PRESSURE RELATIONSHIP : A NEW INDEX INDEPENDENT FROM PERFUSION PRESSURE
• -0941-CHARACTERISTICS OF CORONARY BLOOD FLOW VELOCITY WAVEFORM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0146-CHANGES OF POSTEXTRASYSTOLIC POTENTIATION DURING ACUTE MYOCARDIAL ISCHEMIA AND EARLY REPERFUSION IN DOGS : EFFECTS OF REGIONAL MYOCARDIAL BLOOD FLOW
• APPLICATION OF THROMBIN-ANTITHROMBIN III COMPLEX FOR DETECTING A LATENT HYPERCOAGULABLE STATE IN PATIENTS WITH CORONARY ARTERY DISEASE
• Ebstein Anomaly Associated With Unusual Conduction Delay and Sick Sinus Syndrome : A Case Report
• Echocardiographic Diagnosis of Pulmonary Vein Varix
• Assessment of Takotsubo (ampulla) cardiomyopathy using ^Tc-tetrofosmin myocardial SPECT : Comparison with acute coronary syndrome
• ACE Inhibitor Improves Impaired Myocardial Energy Metabolism and Diastolic Function as Well as Left Ventricular Hypertrophy inHypertensive Patients
• Increased Blood Pressure, Drinking, and Salt Preference by Neuron-Specific Expression of Human Renin
• Inhibition of ACE attenuates apoptosis via bradykinin B_2 receptor and preserves Bcl-xL expression in the ischemia-reperfused rat heart
• A Novel Mechanism of Ethanol-Induced Cardiac Myocytes Injury
• Effects of Pravastatin on Exercise Electrocardiography Test Performance and Cardiovascular Mortality and Morbidity in Patients With Hypercholesterolemia : Lipid Intervention Study in Kyoto
• Successful Catheter Ablation Against Ventricular Tachycardia Associated with Myotonic Dystrophy
• Difference in the Incidence of Cough Induced by Angiotensin Converting Enzyme Inhibitors: a Comparative Study Using Imidapril Hydrochloride and Enalapril Maleate
• Reverse redistribution of Tc-99m-tetrofosmin in exercise myocardial SPECT in patients with hypertrophic cardiomyopathy
• USEFULNESS OF MYOCARDIAL IMAGING USING ^I-BMIPP IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : COMPARISON OF REGIONAL MYOCARDIAL FATTY ACID METABOLISM AND CARDIAC FUNCTION
• ECHO/DOPPLER DIAGNOSIS OF TETRALOGY OF FALLOT, VENTRICULAR SEPTAL DEFECT, PULMONARY VALVE DYSPLASIA, AND HYPERTROPHIC CARDIOMYOPATHY IN WKY/NCrj RATS
• -P228- THE EVALUATION OF SUPER ACUTE ISCHEMIC ARE AFTER RECANALIZATION THERAPY OF ACUTE MYOCARDIAL INFARCTION BY I-123 MIBG SCINTIGRAPHY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -1179-THE CLINICAL SIGNIFICANCE OF 123-I-MIBG MYOCARDIAL SCINTIGRAPHY IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0946-ASESSMENT OF TRANSIENT DILATION OF THE LEFT VENTRICULAR CAVITY IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY BY EXERCISE THALLIUM-201 SCINTIGRAPHY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0287-ECHOCARDIOGRAPHIC ASSESSMENT OF CARDIOMYOPATHY IN BIO 14.6 SYRIAN HAMSTERS
• -P91-PARADOXICAL FLOW : A NEWLY OBSERVED INTRAVENTRICULAR FLOW DYNAMICS IN HYPERTROPHIC CARDIOMYOPATHY : Echocardiography, Pulsed Doppler : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• INFLUENCE OF ENDOTHELIN ON HUMAN PLATELET AGGREGATION AND PROSTACYCLIN GENERATION FROM HUMAN VASCULAR ENDOTHELIAL CELLS IN CULTURE
• EFFECTS OF REDUCTION OF CONTRACTILE WORK ON MECHANICAL FUNCTION IN POST HYPOXIC GUINEA PIG PAPILLARY MUSCLES AND ON MYOCARDIAL ENERGY METABOLISM IN POST-ISCHEMIC RAT HEARTS
• Cardiac Sarcoidosis Mimicking Right Ventricular Dysplasia
• -0523-DIABETIC RAT PAPILLARY MUSCLES ARE RESISTANT TO HYPOXIA : POSSIBLE ROLE OF ALTERED SARCOPLASMIC RETICULUM FUNCTION
• -1199-ELECTROPHYSIOLOGIC EFFECT OF MEXILETINE ON ATRIAL VULNERABILITY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0569-INVESTIGATION OF THE MECHANISM OF STUNNED MYOCARDIUM IN GUINEA PIG PAPILLARY MUSCLES FROM THE VIEWPOINT OF ABNORMALITY IN CALCIUM HOMEOSTASIS
• -0320-ISSUES ON CLINICAL EVALUATION OF ATRIAL VULNERABILITY BY HIGH RIGHT ATRIAL ACTIVITY WIDTH
• SUPPRESSING EFFECTS OF CAFFEINE ON POSTEXTRASYSTOLIC POTENTIATION IN PAPILLARY MUSCLES OF GUINEA PIGS
• THE EFFECTS OF ADENOSINE TRIPHOSPHATE ON ATRIOVENTRICULAR NODE AUTOMATICITY : Cardiovascular Drugs : 53 Annual Scientific Meeting, Japanese Circulation Society
• -P1-EFFECT OF PACED CYCLE LENGTH ON SINUS NODE EFFECTIVE REFRACTORY PERIOD IN MAN : Electrophysiology : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• COMBINED EFFECTS OF HYPOXIA AND ELIMINATION OF GLUCOSE ON RESTING AND POSTEXTRASYSTOLIC POTENTIATED CONTRACTIONS OF PAPILLARY MUSCLE OF GUINEA PIGS
• -459-MEASUREMENT OF CROSS SECTIONAL AREA OF CORONARY ARTERY BY QUANTITATIVE CORONARY ANGIOGRAPHY : Ischemic Heart Disease I : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -284-QUANTITATIVE EVALUATION OF COLLATERAL-DEPENDENT REGIONAL MYOCARDIAL PERFUSION BY DIGITAL SUBTRACTION ANGIOGRAPHY : Ischemic Heart Disease II : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCI
• The Effects of an Extra-stimulation on Post-extrasystolic Potentiation in Papillary Muscle of Rats
• Effects of Hypoxia and Reoxygenation on Steady-state and Potentiated Contractions in Papillary Muscle of Guinea Pigs.
• Effects of Hypoxia and Reoxygenation on Regular Contractions and Postrest Contraction in Rat Papillary Musles.
• The contribution of an extrasystole to postextrasystolic potentiation in papillary muscles of guinea pigs.
• Effects of Caffeine on Ischemia-Reperfusion Injury in Isolated Rat Hearts.
• Effects of Pilsicainide on the Atrial Fibrillation Threshold in Guinea Kg Atria. A Comparative Study with Disopyramide, Lidocaine and Flecainide.:A Comparative Study with Disopyramide, Lidocaine and Flecainide

もっと見る 閉じる

スポンサーリンク