COMBINED EFFECTS OF HYPOXIA AND ELIMINATION OF GLUCOSE ON RESTING AND POSTEXTRASYSTOLIC POTENTIATED CONTRACTIONS OF PAPILLARY MUSCLE OF GUINEA PIGS
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概要
- 論文の詳細を見る
We studied the combined effects of hypoxia and the absence of glucose on postextrasystolic potentiated and resting contractions in papillary muscle of guinea pigs. Postextrasystolic potentiations (PESPs) were evoked following trains of 40 externally applied continuous stimulations. During hypoxia resting (regular) contractions decreased to about 25% of baseline tension at 30℃, whereas postextrasystolic potentiated contractions decreased to about 35% of baseline measurement of postextrasystolic potentiated contraction. In contrast, with reoxygenation, PESPs recovered quickly while resting contractions recovered gradually. Caffeine abolished the potentiation of postextrasystolic contraction not only in normoxia but also in hypoxia. We speculate that calcium release from the sarcoplasmic reticulum (SR) is attributable to PESP for the most part, and that the trans-sarcolemmal calcium influx generally contributes to the steady-state tensions developed by continuous stimulations. In addition, it seems that PESP works in a ischemic heart to compensate for the decreased tension during hypoxia as a potentiation by a premature ventricular contraction. Trans-sarcolemmal calcium influx might be affected more easily than the SR calcium release, by a combination of hypoxia and the absence of glucose, that is, the sarcolemma may be more susceptible to hypoxic injury than the SR.
- 社団法人日本循環器学会の論文
- 1989-04-20
著者
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Tatsumi Tetsuya
Department Of Cardiovascular Medicine Nantan General Hospital
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Tatsumi Tetsuya
京都第一赤十字病院 循環器科
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Tatsumi Tetsuya
Second Department of Medicine, Kyoto Prefectural University of Medicine
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Nakagawa Masao
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Tatsumi T
Kyoto Prefectural University Of Medicine
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Inoue Daisuke
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Tatsumi Tetsuya
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Asayama Jun
Second Department of Medicine, Kyoto Prefectural University of Medicine
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Omori Itsuki
Second department of medicine, Kyoto Prefectural University of Medicine
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Katsume Hiroshi
Second department of medicine, Kyoto Prefectural University of Medicine
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Asayama Jun
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Katsume Hiroshi
The 2nd Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Tatsumi Tetsuya
First Department Of Internal Medicine Nara Medical University
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Omori Itsuki
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Katsume Hiroshi
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Tatsumi T
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Tatsumi Tetsuya
Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Nakagawa Masao
Second Department Of Internal Medicine Kyoto Prefectural Medical College
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Inoue Daisuke
Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Inoue Daisuke
The 2nd Division Of Internal Medicine Kyoto Prefectural University Of Medicine
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KATSUME Hiroshi
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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ASAYAMA Jun
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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INOUE Daisuke
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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