Intracoronary Transplantation of Non-Expanded Peripheral Blood-Derived Mononuclear Cells Promotes Improvement of Cardiac Function in Patients With Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Background Transplantation of non-expanded peripheral blood mononuclear cells (PBMNCs) enhances neovessel formation in ischemic myocardium and limbs by releasing angiogenic factors. This study was designed to examine whether intracoronary transplantation of PBMNCs improves cardiac function after acute myocardial infarction (AMI). Methods and Results After successful percutaneous coronary intervention (PCI) for a ST-elevation AMI with occlusion of proximal left anterior descending coronary artery within 24 h, patients were assigned to either a control group or the PBMNC group that received intracoronary infusion of PBMNCs within 5 days after PCI. PBMNCs were obtained from patients by COBE spectra-apheresis and concentrated to 10ml, 3.3ml of which was infused via over-the-wire catheter. The primary endpoint was the global left ventricular ejection fraction (LVEF) change from baseline to 6 months' follow-up. The data showed that the absolute increase in LVEF was 7.4% in the control group and 13.4% (p=0.037 vs control) in the PBMNC group. Cell therapy resulted in a greater tendency of ARegional ejection fraction (EF) or significant improvement in the wall motion score index and Tc-99m-tetrofosmin perfusion defect score associated with the infarct area, compared with controls. Moreover, intracoronary administration of PBMNCs did not exacerbate either left ventricular (LV) end-diastolic and endsystolic volume expansion or high-risk arrhythmia, without any adverse clinical events. Conclusion Intracoronary infusion of non-expanded PBMNCs promotes improvement of LV systolic function. This less invasive and more feasible approach to collecting endothelial progenitor cells may provide a novel therapeutic option for improving cardiac function after AMI.
- 社団法人日本循環器学会の論文
- 2007-07-20
著者
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Hadase Mitsuyoshi
Department of Cardiology, Saiseikai Shigaken Hospital
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Uemura Shiro
First Department of Medicine, Nara Medixal University
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Okayama Satoshi
First Department of Medicine, Nara Medixal University
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Horii Manabu
First Department of Medicine, Nara Medixal University
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UMEMURA Satoshi
Yokohama City University
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NAKAMURA Reo
Department of Cardiology, Kouseikai Takeda Hospital
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IRIE Hidekazu
Department of Cardiology, Kouseikai Takeda Hospital
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NISHIKAWA Susumu
Department of Cardiovascular Medicine, Nantan General Hospital
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TATSUMI Tetsuya
Department of Cardiovascular Medicine, Nantan General Hospital
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Matsui Akihiro
Department of Cardiolgy, Kyoto Prefectural University of Medicine
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Katamura Maki
AMI-Kyoto Multi-Center Risk Study Group
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Matsunaga Shinsaku
Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine
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Matoba Satoaki
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Nishikawa Susumu
Department Of Cardiovascular Medicine Nantan General Hospital
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Ashihara Eishi
Department of Transfusion Medicine and Cell Therapy (E.A., T.M.), Kyoto University Hospital
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Ashihara Eishi
Department Of Transfusion Medicine And Cell Therapy (e.a. T.m.) Kyoto University Hospital
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Ashihara E
京都府立医科大学 第2内科学
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Ashihara Eishi
Department Of Transfusion Medicine And Cell Therapy Kyoto University Hospital
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Ashihara Eishi
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto Prefectural University Of Me
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Tatsumi Tetsuya
Kyoto Prefectural University Of Medicine
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Tatsumi Tetsuya
Department Of Cardiovascular Medicine Nantan General Hospital
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Okayama Satoshi
First Department Of Internal Medicine Nara Medical University
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Uemura Shiro
First Department Of Internal Medicine Nara Medical University
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Horii Manabu
First Department Of Internal Medicine Nara Medical University
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Umemura Satoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Ashihara E
Department Of Transfusion Medicine And Cell Therapy Kyoto University Hospital
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Kido Atsumichi
Department of Cardiovascular Medicine, Nantan General Hospital
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Kido Atsumichi
First Department Of Internal Medicine Nara Medical University
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Katamura Maki
Department Of Cardiology Kyoto Second Red Cross Hospital
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Nakamura Reo
Department Of Cardiology Kouseikai Takeda Hospital
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Tatsumi Tetsuya
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Hadase Mitsuyoshi
Kyoto First Red Cross Hospital
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Kido Atsumichi
Department Of Cardiology Cardiovascular Center Kosekai Takai Hospital
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Kido Atsumichi
Department Of Cardiology Nantan General Hospital
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Matsuo Akiko
Department Of Cardiology Kyoto First Red Cross Hospital
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Yasui Toshihide
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Koide Masahiro
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Ito Kazuki
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Matsui Hiroyuki
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Kusuoka Shigehiro
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Tsuji Hajime
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Sasada Yuji
Blood Transfusion and Cell Therapy, Kyoto Prefectural University School of Medicine
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Nishikawa Satoshi
Radiology, Kyoto Prefectural University School of Medicine
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Shimazaki Chihiro
Hematology and Oncology, Kyoto Prefectural University School of Medicine
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Tsuji Hajime
Blood Transfusion and Cell Therapy, Kyoto Prefectural University School of Medicine
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Shimazaki C
Department Of Molecular Hematology And Oncology Graduate School Of Medical Science Kyoto Prefectural
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Shimazaki Chihiro
Division Of Hematology And Oncology Department Of Medicine Graduate School Of Medical Science Kyoto
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Shimazaki Chihiro
京都府立医科大学
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Saito Yoshihiko
First Department Of Internal Medicine Nara Medical University
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Sasada Yuji
Blood Transfusion And Cell Therapy Kyoto Prefectural University School Of Medicine
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Koide Masahiro
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Koide Masahiro
Department Of Cardiology Kyoto Prefectural University Of Medicine
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Hadase Mitsuyoshi
Department Of Cardiology Saiseikai Shigaken Hospital
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Hadase Mitsuyoshi
Department Of Cardiology Kyoto First Red Cross Hospital
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Irie Hidekazu
Department Of Cardiology Kouseikai Takeda Hospital
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Irie Hidekazu
Department Of Anatomy And Developmental Biology
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Matsui Akihiro
Departments Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Arihara Masayasu
Department Of Emergency Medicine Kyoto First Red Cross Hospital
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Kusuoka Shigehiro
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Ito Kazuki
犬山中央病院 循環器内科
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Ito Kazuki
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Ito Kazuki
Department Of Cardiology Inuyama Chuuou Hospital
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Katamura Maki
Department Of Cardiology Kyoto First Red Cross Hospital
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Tsuji Hajime
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Kobara Miyuki
Departments Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Kobara Miyuki
Department Of Clinical Pharmacology Kyoto Pharmaceutical University
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Kobara Miyuki
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Tatsumi Tetsuya
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Matoba Satoaki
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Matoba Satoaki
Department Of Cardiovascular Medicine Kyoto Prefactural University Of Medicine
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Sugiura Yuki
Department Of Molecular Anatomy Hamamatsu University School Of Medicine
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Ishibashi Kazuya
Kyoto AMI Research Group
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Yasui Toshihide
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Yasui Toshihide
Departments Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Tatsumi Tetsuya
First Department Of Internal Medicine Nara Medical University
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Hadase Mitsuyoshi
Departments Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Shimazaki Chihiro
Hematology And Oncology Kyoto Prefectural University School Of Medicine
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Kimata Masaki
Department Of Cardiology Kyoto First Red Cross Hospital
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Saitoh Yoshihiko
The Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
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Nishizawa Shinya
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Tatsumi Tetsuya
Department Of Cardiology Nantan General Hospital
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Nishikawa Susumu
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Ito K
Department Of Brain Science And Molecular Imaging National Institute For Longevity Science National
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Matsunaga Shinsaku
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Tatsumi T
First Department Of Medicine Nara Medical University
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Matsunaga Shinsaku
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Matsubara Hiroaki
Department Of Bioscience National Cardiovascular Center Research Institute
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Matoba Satoaki
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Uemura Shiro
1st Dept. Of Int. Med. Nara Medical University
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Shimazaki Chihiro
Division Of Hematology And Oncology Department Of Medicine Graduate School Of Medical Science Kyoto Prefectural University Of Medicine
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MATSUI Hiroyuki
Department of Advanced Materials Science, University of Tokyo
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Tatsumi Tetsuya
Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University School of Medicine
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