The Effects of an Extra-stimulation on Post-extrasystolic Potentiation in Papillary Muscle of Rats

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概要

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• The mechanism of post-extrasystolic potentiation (PESP) is unclear. It has previously been suggested that changes in both the calcium release from the sarcoplasmic reticulum (SR) and the transsarcolemmal calcium influx are factors in the development of PESP in guinea-pigs. This experiment investigated the effects of a resting interval and a coupling interval on PESP in rat papillary muscles, which have a well-developed SR. An extra-stimulation was induced at various coupling intervals and a variety of post-extrasystolic intervals were set. The PESP was not dependent on the coupling interval. The post-extrasystolic interval at which the maximal % PESP was obtained was about 90 sec, and post-extrasystolic interval-% potentiation of the PESP relationship curve consisted of an ascending limb and a descending limb. Caffeine eliminated the PESP in a concentration-dependent manner. These findings suggest that SR calcium release plays an important role in the mechanism of PESP in rats. This is consistent with results from guinea-pigs, and implies that the calcium capacity and/or retention of the SR may characterize the post-extrasystolic interval-% PESP relationship in muscle from different species.

著者

• Shirayama Takeshi

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• MIYAZAKI Hiroshi

  Second Department of Medicine,Kyoto Prefectural University of Medicine

• Omori Itsuki

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Tatsumi Tetsuya

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Nakagawa Masao

  Second Department Of Internal Medicine Kyoto Prefectural Medical College

• ASAYAMA Jun

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• INOUE Daisuke

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• SHIRAYAMA Takeshi

  Second Department of Medicine, Kyoto Prefectural University of Medicine

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