Sequence of electrophysiological property and metabolic disorder in ischemic myocardium.

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The relationships of electrical changes to the time course of reduction in adenosine triphosphate (ATP) content were examined in 41 dogs with coronary artery ligation and 14 control dogs. Twenty dogs with malignant ventricular arrhythmias within 10min of ischemia (VA dogs) were characterized by widening of the composite electrogram duration (147±47msec at 5min). In con-trast, the composite electrogram duration was narrower (71±12 msec at 5min, p<0.001) in 21 dogs without malignant arrhythmias (non-VA dogs). The degree of ATP reduction in VA dogs was significantly less at 3min (3.11±0.28μmol•g-1, p<0.05) and at 5min (2.93±0.28μmol•g-1, p<0.05) than in non-VA dogs (2.76±0.22μmol•g-1, 2.39±0.44μmol•g-1, respectively). The width of the electrograms in VA dogs decreased gradually after 10min of ischemia, and it was not significantly different from non-VA dogs by 13min, which coincided with disappearance of a difference in ATP content (2.10±0.34μmol•g-1 and 2.35±0.23μmol•g-1 in VA dogs and non-VA dogs biopsied at 10-20min of ischemia). It was concluded that the metabolic deterioration in VA dogs advanced more slowly than that in non-VA dogs within 5min of ischemia and the decrease in the width of the electrogram after 10min did not result from a partial recovery of ischemia.
International Heart Journal刊行会の論文