Suppression of renal sympathetic activity with potassium supplement in DOCA-salt rats.
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概要
- 論文の詳細を見る
We studied the involvement of renal sympathetic nervous system activity in the antihypertensive and natriuretic effects of potassium supplement in DOCA-salt treated rats. Systolic blood pressure of DOCA-salt rats rose substantially, reaching 181±3mmHg after 4 weeks of DOCA-salt administration. In contrast, the supplement of 1% KCl solution attenuated the development of the hypertension until the fourth week (120±1mmHg). After the 4-week treatments, renal norepinephrine turnover rate was calculated from the decline in specific activity after the injection of dl-3H-norepinephrine. It was markedly accelerated in DOCA-salt rats as compared to control rats. In contrast, 1% KCl supplement significantly restored to normal the increased renal norepinephrine turnover rate in DOCA-salt rats. Taken together, evidence presented suggests that the normalization of the increased renal sympathetic tone may be involved in the natriuretic and antihypertensive effects of potassium supplement in DOCA-salt hypertensive rats.
- International Heart Journal刊行会の論文
著者
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Fujita Toshiro
Department Of Cardiovascular Medicine University Of Tokyo School Of Medicine
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Sato Yuji
Department Of Bacteriology National Institute Of Health
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FUJITA TOSHIRO
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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