Natulan (Procarbazine hydrochloride)の中枢作用について

概要

論文の詳細を見る
Natulan brought about a sedative effect with neither hypnotic nor anesthetic effect in the rabbit, and showed a drowsy pattern in the spontaneous EEG activity. The EEG arousal response to auditory was markedly depressed by Natulan, while the arousal response elicited by electrical stimulation of the midbrain reticular formation tended to be depressed by this drug. The recruiting response was not influenced by the drug.<BR> Locomotor activity of the rat in open field test was not affected by Natulan, and the drug did not induce an analgesic effect and a muscle relaxing effect in inclined screen test in the mouse. The drug prolonged hexobarbital induced sleeping time in the mouse and showed a weak cataleptogenic effect in the mouse. Natulan elicited a anticonvulsive effect on pentetrazol convulsion, whereas it showed no influence upon maximal electroshock convulsion.<BR> These pharmacological effects of Natulan were observed when it was administered in large doses.<BR> From the result, it has been suggested that Natulan acts inhibitory on the central nervous system when it is used in large doses.
社団法人日本薬理学会の論文