鶏の血管内への薬物の注入と盲腸内への排出について〔鶏の盲腸機能に関する研究-19-〕

概要

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The excretion of intravenously-injected drugs into the cecum of Single Comb White Leghorn chicks was investigated using the intestinal perfusion technique. 1. (35S)-sulphobromophthalein supplied intravenously by injection was found in both the small intestine and ceca. The amount of sulphobromophthalein in the small intestine was 80% of that in the ceca. 2. Intravenously-injected (7-3H)-tetracyclin was also found in both the small intestine and ceca: the amount in the ceca was proportional to the dose injected. The amount of tetracyclin in the small intestine was 70-50% of that in the ceca. 3. The amount of sulfisoxazolum was increased in the ceca proportionally with an increase of intravenously-injected sulfisoxazolum, whereas that in the small intestine was unchanged. 4. The amount of (14C)-carbaryl in the ceca increased proportionally with an increase of intravenously-injected (14C)-carbaryl: the amount in the small intestine was about a-third in the ceca. 5. From the results obtained in the present experiment, it is considered that the cecum of chickens has a function of excreting foreign substances that enter into the body occasionally.
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