Thymoma and multiple thymic cysts in a dog with acquired myasthenia gravis
スポンサーリンク
概要
- 論文の詳細を見る
An anterior mediastinal cystic lesion in an 11-year-old mongrel dog was examined. The dog showed dysbasia and vomiting due to megaoesophagus, and anterior mediastinal round mass lesion, approximately 35 mm in diameter, was found by X ray. Based on clinical examinations, the dog was diagnosed as acquired myasthenia gravis and was successfully controlled by anticholinesterase treatment for approximately 4 months. The dog died of thermic stroke and was necropsied. Grossly, fatty tissues with cysts containing yellowish fluid and white nodules were found in the anterior mediastinal area. Histopathologically, multiple cysts, neoplastic tissues, and atrophic thymus were found within the examined tissues. The cysts were lined by thin wall consisting of ciliated long cuboidal and nonciliated round cells and were filled with eosinophilic colloidal fluid. Some extended cysts contained neoplastic foci within their lumen and walls. The neoplastic tissues consisted of mixed population of large epithelial cells with abundant clear cytoplasm and large oval nuclei, and lymphocytes. Immunohistochemically, proliferating epithelial cells were intensely positive for keratin and cytokeratin, and more than half number of infiltrating lymphocytes were intensely positive for CD3 suggesting T cells. All these findings indicate the neoplastic lesion is thymoma and multiple cysts are considered as thymic or brachial cleft cysts.11歳雑種犬の前縦隔部に認められた嚢胞性病変を検索した.本例は虚脱と巨大食道症に起因する嘔吐を示し,X線により前縦隔部に直径約35mmの球形腫瘤病変が確認された.臨床試験により本例は後天性重症筋無力症と診断され,抗コリンエステラーゼ薬治療で約4ヶ月間良好に維持された.本例は熱性ショックにより死亡し剖検された.肉眼的に前縦隔部には,黄色調液体を貯留する嚢胞と白色結節を含む脂肪組織が認められた.組織学的に同組織には,多発性嚢胞,腫瘍組織,および萎縮した胸腺が含まれていた.嚢胞は長立方形の線毛上皮と円形非線毛上皮からなる薄い嚢胞壁から構成され,内部に好酸性コロイドを有していた.一部の拡張した嚢胞内及び嚢胞壁には腫瘍組織がみとめられ,この腫瘍組織は,淡明な細胞質と大型円形核を有する大型上皮細胞とリンパ球から構成されていた.免疫組織化学的に上皮細胞はケラチンおよびサイトケラチン強陽性で,浸潤していたリンパ球の半数以上がCD3陽性でありT細胞と考えられた.以上の検索結果より腫瘍性病変は胸腺腫,多発性嚢胞は胸腺嚢胞あるいは遺残鰓弓性嚢胞と考えられた.
著者
-
Awamura Yuichi
Totsuka Animal Hospital
-
TATEYAMA Susumu
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
-
Uchida Kazuyuki
Department Of Veterinary Pathology Graduated School Of Agricultural And Life Sciences The University
-
Nakamura Tomoko
Department of Allergy and Immunology, National Research Institute for Child Health and Development, National Center for Child Health and Development
-
内田 和幸
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
-
粟村 雄一
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
関連論文
- Fibrinoid Leukodystrophy (Alexanders Disease-Like Disorder) in a Young Adult French Bulldog
- A Case of Recovery from Canine Destructive Cholangitis in a Miniature Dachshund
- Morphology of the Digestive System in the Wood-Feeding Termite Nasutitermes takasagoensis (Shiraki) [Isoptera : Termitidae](Morphology)
- Clinicopathological features of canine neuroaxonal dystrophy and cerebellar cortical abiotrophy in papillon and papillon-related dogs
- Immunohistochemical detection of tau protein in various non-human animal brains
- Systemic T Cell Large Granular Lymphocyte Lymphoma with Multifocal White Matter Degeneration in the Brain of a Japanese Domestic Cat
- HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman's disease
- Expression and Antigenicity of Human Herpesvirus 8 Encoded ORF59 Protein in AIDS-Associated Kaposi's Sarcoma
- MALIGNANT LYMPHOMA IN IMMUNOCOMPROMISED HOSTS
- A Retrospective Study in 21 Shiba Dogs with Chronic Enteropathy
- DEVELOPMENTALLY DELAYED SENSITIVITY OF ACETYLCHOLINE RECEPTOR IN MYOTUBES OF NERVE-MUSCLE COCULTURES FROM GENETICALLY DIABETIC MOUSE EMBRYOS
- Long Term Survival of Primary Skeletal Muscle Lymphoma in a Miniature Dachshund
- Histiocytic Sarcoma in the Brain of a Cat
- Suppressive Effects of Perilla frutescens on Mesangioproliferative Glomerulonephritis in Rats
- Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed
- Prevalence of Autoantibody in Cerebrospinal Fluids from Dogs with Various CNS Diseases
- A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs
- Efficacy of plasma exchange therapy for Kawasaki disease intractable to intravenous gamma-globulin
- Symptomatic Tongue Atrophy Due to Atypical Polymyositis in a Pembroke Welsh Corgi
- Latent cerebral hypoperfusion in a boy with persistent nephrotic syndrome
- Usefulness of serum fibrinogen degradation product-E in sporadic cases of classical hemolytic uremic syndrome
- Hamartoma in the Medulla Oblongata with Marked Mineral Deposits in a Dog
- Comparison between Immunohistochemistry and Genetic Clonality Analysis for Cellular Lineage Determination in Feline Lymphomas
- Peripheral Neuroblastoma and Primitive Neuroectodermal Tumor in Japanese Black Cattle
- Immunohistochemical Observation of Canine Degenerative Myelopathy in Two Pembroke Welsh Corgi Dogs
- Neuroblastoma of the Adrenal Gland in a Ferret
- Peripheral Neuroblastoma in a Young Labrador Retriever
- Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimers Brain
- Thymoma and multiple thymic cysts in a dog with acquired myasthenia gravis
- Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period
- Primary Intra-Axial B-Cell Lymphoma in a Cat(Surgery)
- SHEAR STRENGTH OF REINFORCED CONCRETE BEAMS WITH WELDED WIRE MESHES
- A Case of Canine Multiple Inflammatory Colorectal Polyps Treated by Endoscopic Polypectomy and Argon Plasma Coagulation
- The Binding of Curcumin to Various Types of Canine Amyloid Proteins
- Age-related histological changes in the canine substantia nigra
- Treatment of macular edema due to branch retinal vein occlusion with single or multiple intravitreal injections of bevacizumab
- Mammary Lipid-Rich Carcinoma with Extensive Amyloid Deposition in a Dog
- Long-Term Survival in a Dog with Anaplastic Oligodendroglioma Treated with Radiation Therapy and CCNU
- Pathological Features of Polyneuropathy in Three Dogs
- Polypoid Adenomas Secondary to Inflammatory Colorectal Polyps in 2 Miniature Dachshunds
- Intestinal T-Cell Lymphoma with Severe Hypereosinophilic Syndrome in a Cat
- Lymphangiomatosis of the Systemic Skin in an Old Dog
- Diffuse Bilateral Hemangiosarcoma of the Uterus in a Dog
- Immunization against Intestinal Bacterial Endotoxin Prevents Alcoholic Fatty Liver in Rats
- A Pathologic Study on Ocular Disorders in Calves in Southern Kyushu, Japan
- Changes of MAO-A and MAO-B Expressions in the Placenta of MPTP or MPP+ Treated Mice
- Value of the 13C-Urea Breath Test for Detection of Gastric Helicobacter spp. Infection in Dogs Undergoing Endoscopic Examination
- Histopathological Studies on Cases of Chronic Mouse Hepatitis by Natural Helicobacter Infections
- Spontaneous Tyzzer's Disease with the Central Nerve Involvement in a Newborn Common Marmoset
- Depolarizing effects of glycyrrhizin-derivatives relating to the blend effects with paeoniflorin in mouse diaphragm muscle.
- Reaction of organocobaloxime with thiol under irradiation.
- Occurrence of Spontaneous Tumors in the Central Nervous System (CNS) of F344 and SD Rats
- Alloxan-diabetic state-induced suppression of Ca2+-dependent slow action potentials in mouse diaphragm muscle.
- Immunohistochemical Analysis of c-yes and c-erbB-2 Oncogene Products and p53 Tumor Suppressor Protein in Canine Mammary Tumors.
- Biochemical evaluation of the neurotoxicity of MPTP and MPP^+ in embryonic and newborn mice