Effect of Protein Malnutrition on Skin Epidermis of Hairless Mice
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概要
- 論文の詳細を見る
The purpose of this study was to evaluate the effect of protein malnutrition on skin epidermis of mice. The low protein diet induced the thinning of skin epidermis, the decrease of cell proliferative activity in epidermal cells and the decrease of stratum corneum hydration. Dityrosine was immunostained in the cytoplasm of epidermal cells in the low protein diet group. Plasma advanced oxidation protein product (AOPP) levels were significantly more increased in the low protein diet group than the control diet group. These results suggest that protein malnutrition adversely affects the structure and water-barrier and reservoir function of the skin epidermis, and these pathological changes are associated with the expressions of protein oxidation markers, dityrosine and AOPP.
著者
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杉山 晶彦
鳥取大学農学部
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Suzuki Yasushi
Biochemical Laboratory, Saraya Company, Ltd.
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Sugiyama Akihiko
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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TAKEUCHI Takashi
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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FUJITA Yuka
Courses of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, To
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MASUDA Aino
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
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OCHI Tairin
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
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Ryu Mizuyuki
Biochemical Laboratory Saraya Co. Ltd.
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KOBAYASHI Toshihiro
Biochemical Laboratory, Saraya Co., Ltd.
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Suzuki Yasushi
Biochemical Laboratory Saraya Company Ltd.
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MASUDA Aino
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co.
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OCHI Tairin
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co.
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FUJITA Yuka
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
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