Effects of Polyphenols from Seed Shells of Japanese Horse Chestnut (Aesculus turbinata BLUME) on Methotrexate-Induced Intestinal Injury in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to evaluate the effects of polyphenols from seed shells of Japanese horse chestnut (JHP) on methotrexate (MTX)-induced intestinal injury in rats. MTX application caused intestinal morphological injury and increase in malondialdehyde (MDA) levels, decrease in levels of glutathione (GSH) and glutathione peroxidase (GSH-Px) activities in small intestine. However, oral administration of JHP ameliorated MTX-induced intestinal injury and inhibited the increase in MDA and the decrease in GSH and GSH-Px activity in small intestine. In conclusion, our results indicated that oral administration of JHP alleviated MTX-induced intestinal injury through its antioxidant properties.
著者
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Sugiyama Akihiko
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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TAKEUCHI Takashi
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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Ogawa Satoshi
Department Of Anatomy And Neuroscience Osaka University Medical School
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YOKOTA Kazushige
Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University
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KIMURA Hideto
Department of Research and Development, Kotobuki Seika Co., Ltd.
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