Expressions of Protein Oxidation Markers, Dityrosine and Advanced Oxidation Protein Products in Cisplatin-Induced Nephrotoxicity in Rats
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概要
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The purpose of this study was to evaluate whether dityrosine and advanced oxidation protein products (AOPP) reflect the severity of cisplatin-induced nephrotoxicity. Immunoexpression of dityrosine in kidneys and plasma AOPP concentration were examined up to day 4 post-cisplatin injection in rats. Cisplatin injection induced tubular injury on days 2–4 after injection and increased serum creatinine and BUN on days 3 and 4. On days 2–4, dityrosine was immunostained in the cytoplasm of damaged tubular cells, and their immunostaining intensity increased time-dependently. Plasma AOPP levels were significantly increased on days 3 and 4. These results suggest that expressions of dityrosine and AOPP were associated with the severity of renal injury and may be useful markers for the development of cisplatin-induced nephrotoxicity.
著者
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杉山 晶彦
鳥取大学農学部
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Sugiyama Akihiko
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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TAKEUCHI Takashi
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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NISHINOHARA Masaaki
Courses of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, To
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MASUDA Aino
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
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OCHI Tairin
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
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KIMOTO Yumi
United Graduate School of Veterinary Science, Yamaguchi University
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ASANO Atsushi
Course of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori Un
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TAKEUCHI Takashi
United Graduate School of Veterinary Science, Yamaguchi University
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NISHINOHARA Masaaki
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
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MASUDA Aino
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co.
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OCHI Tairin
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co.
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