Expressions of Lipid Oxidation Markers, Nε-Hexanoyl Lysine and Acrolein in Cisplatin-Induced Nephrotoxicity in Rats
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概要
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The purpose of this study was to evaluate whether Nε-hexanoyl lysine (Nε-HEL) and acrolein reflect the severity of cisplatin-induced nephrotoxicity. Immunoexpression of Nε-HEL and acrolein in kidneys and their urinary concentration were examined up to day 4 post-cisplatin injection in rats. Cisplatin-induced tubular injury was observed histopathologically on days 2–4 after injection and became more severe time-dependently. On days 2–4, Nε-HEL and acrolein were immunostained in the cytoplasm of damaged tubular cells. Their immunostaining intensity and urinary levels increased as tubular injury became more severe. These results suggest that expressions of Nε-HEL and acrolein were associated with the pathogenesis of cisplatin-induced nephrotoxicity.
著者
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杉山 晶彦
鳥取大学農学部
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Sugiyama Akihiko
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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TAKEUCHI Takashi
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tot
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SUN Jing
Courses of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, To
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NISHINOHARA Masaaki
Courses of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, To
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FUJITA Yuka
Courses of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, To
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MASUDA Aino
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
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OCHI Tairin
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
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NISHINOHARA Masaaki
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
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MASUDA Aino
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co.
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SUN Jing
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
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OCHI Tairin
Japan Institute for the Control of Aging (JalCA), Nikken Seil Co.
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FUJITA Yuka
Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
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