雌WBN/Kob-fattyラットの糖尿病および膵炎発症に対する制限給餌の影響
スポンサーリンク
概要
- 論文の詳細を見る
Original WBN/Kob male rats commonly develop chronic pancreatitis by the age of 3 months, while diabetes mellitus occurs at 9 months. In contrast, female rats of this strain do not show pancreatitis or diabetes. The WBN/Kob-fatty rat is a homozygous (fa/fa) congenic strain for the fa allele of the leptin receptor gene (Lepr). In WBN/Kob-fatty rats, both females and males provide a model of non-insulin-dependent diabetes with obesity. The leptin receptor fatty gene (Leprfa) induces obesity and hyperphagia. In the present study, we examined the effect of dietary restriction on pancreatitis and diabetes in female WBN/Kob-fatty rats. Five female fatty rats comprised a restricted feeding group with paired-feeding from 3 to 13 weeks of age, and five female lean rats comprised a control group with paired-feeding. At 13 weeks of age, two of the five female fatty rats of the control group developed diabetes mellitus, while no female fatty rats of the restricted feeding group developed diabetes mellitus. At this stage, pathological changes of the pancreas were observed in female fatty rats. All female fatty rats showed severe interlobular, intra-lobular and intra-islet fibrosis. In female fatty rats of the restricted feeding group, pathological changes of the pancreas were milder those of the free-feeding fatty group. Although dietary restriction could not completely prevent pancreatitis in female fatty rats, the development of diabetes was inhibited by its reduction of the severity of pancreatitis.
著者
-
SHIMIZU Akira
Department of Electrical and Electronic Engineering, Tokyo Institute of Technology
-
寺田 節
Division of Laboratory Animal Science, Nippon Medical School
-
OZAWA Hitoshi
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine
-
TERADA Misao
Division of Laboratory Animal Science, Nippon Medical School
-
AKIMOTO Toshio
Division of Laboratory Animal Science, Nippon Medical School
-
Terada Misao
Division Of Laboratory Animal Science Nippon Medical School
-
Ozawa Hitoshi
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
-
Akimoto Toshio
Division Of Laboratory Animal Science Nippon Medical School
-
SAWAI Nobuhiko
Department of Anatomy and Neurobiology, Nippon Medical School
-
Shimizu Akira
Deparment Of Physics Rikkyo University
-
Shimizu Akira
Department of Analytic Human Pathology, Nippon Medical School
-
秋元 敏雄
Division of Laboratory Animal Science, Nippon Medical School
-
清水 章
Department of Analytic Human Pathology, Nippon Medical School
-
Sawai Nobuhiko
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine
関連論文
- Improvement of the Electrochemical Profiling Technique of Carrier Concentration in Cu(InGa)Se_2 Thin Film Solar Cells
- 高齢および若齢雄ラットの交尾行動における心拍数の変化
- Electrical and Structural Characterizations of Cu(InGa)Se_2 Thin Films Using Electrochemical Capacitance-Voltage Method and Focused-Ion Beam Process
- UGT1A1^*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients
- Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus
- P2-06 GFP imaging analysis of subcellular localization of androgen receptor and estrogen receptor in a single living cell
- 雌WBN/Kob-fattyラットの糖尿病および膵炎発症に対する制限給餌の影響
- Serum protein profile of rheumatoid arthritis treated with anti-TNF therapy (infliximab)
- P1-14 Morphofunctional study of gonadotropin-releasing hormone neurons in the rat preoptic area
- Current status and issues of C1q nephropathy
- Complete remission of a primary cutaneous follicle-center cell lymphoma (EORTC criteria)/diffuse large B-cell lymphoma (WHO criteria) by single first-line therapy with rituximab
- Developmemt of High-Efficiency CuIn_xGa_Se_2 Thin-Film Solar Cells by Selenization with Elemental Se Vapor in Vacuum
- EXPRESSION OF THE GLUCOCORTICOID RECEPTOR IN RAT IS INVOLVED IN CHANGES IN PROOPIOMELANOCORTIN PROCESSSING PATTERNS
- Cholesterol Crystal Embolization : Skin Manifestation, Gastrointestinal and Central Nervous Symptom Treated with Corticosteroid
- Strong Enhancement of Superconducting Correlation in a Two-Component Fermion Gas
- Differently regulated androgen receptor transcriptional complex in prostate cancer compared with normal prostate
- Case of subcutaneous sparganosis : Use of imaging in definitive preoperative diagnosis
- ラットにおける体重(精巣上体脂肪)および血中レプチンの血液脳関門通過率との関連性
- Comparison of Ultrasonic Vocalizations Emitted by Rodent Pups
- Developmental Expression of Penile Reflexes and Copulatory Behavior in Male Rats
- Hb Bristol-Alesha Presenting Thalassemia-Type Hyperunstable Hemoglobinopathy
- Time-dependent changes in cardiovascular function during copulation in male rats
- Effect of chronic methylene blue administration on hypoxemia in rats with common bile duct ligation
- Viability and Plasma Vitamin K Levels in the Common Bile Duct-Ligated Rats
- Effects of i. c. v. Administration of Leptin on Copulatory and Ingestive Behavior in STZ-induced Diabetic Male Rats
- Successful treatment with bosentan for refractory digital ulcers in a patient with systemic lupus erythematosus
- Topical Tacrolimus Therapy for Erythematous Lesions of Dermatomyositis
- Extramammary Paget's Disease with Bowenoid Histologic Features Accompanied by an Ectopic Lesion on the Upper Abdomen
- Cellular Distribution of a GPI-Anchored Complement Regulatory Protein CD59: Homodimerization on the Surface of HeLa and CD59-Transfected CHO Cells^1
- Isolation of Staphylococcus aureus from Raw Fish in Relation with Culture Methods
- Hemoglobin Variant HbG-Coushatta (β-22 Glu→Ala) Found by Dissociation of Blood Glucose from Values of HbA_1c Measured by HPLC
- Detection of Corynebacterium kutscheri from the Oral Cavity of Rats
- IIA-01 Comparative study of a cichlid, Oreochromis (Tilapia) niloticus and mouse on somatotopic organization of the trigeminal ganglion cells(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- FIBER CONNECTIONS OF THE CORPUS MAMILLARE IN THE TILAPIA (PERCIFORM, TELEOSTEI)
- Preoptic gonadotropin-releasing hormone(GnRH) neurons innervate the pituitary in teleosts
- II-C-05 Immunohistochemical study on the postnatal development of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), SRC-1 and p300 in the rat brain(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Locus of Dominant Hairless Gene (Ht) Causing Abnormal Hair and Keratinization Maps to Rat Chromosome 10
- Case of livedoid vasculopathy with extensive dermal capillary thrombi
- Multicentric Involvement of Non-Hodgkin's Lymphoma in the Central Nervous System and Testis : Case Report
- A Disturbance Estimation Type Control for Pneumatic Servo System Using Neural Network
- A Fundamental Approach of Avoidance Planning of Robots Considering Human Emotions
- Neuro-Fuzzy Control for Pneumatic Servo System
- Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study
- A Case of Giant Undifferentiated Sarcoma of the Liver with Marked Regression after Transarterial Chemoembolization
- Myelopathy Due to Thickened Ligamenta Flava and Abnormal Fibrous Tissue of the Cervicothoracic Junction : Case Report
- Duplication of the inferior vena cava associated with other variations
- Fiber connections of the periventricular pretectal nucleus in a teleost, tilapia (Oreochromis niloticus)
- Dioecy and Pollination of Morinda umbellata subsp. umbellata (Rubiaceae) in the Ryukyu Islands
- Postnatal Development of NADPH-Diaphorase Activity in the Rat: The Role of Nitric Oxide in the Ontogeny of Arginine Vasopression and Oxytocin
- Postnatal development of NADPH-diaphorase activity in the rat hypothalamo-hypophysial axis with special reference to vasopression and oxytocin
- Dysplastic glomerulocystic kidney
- Morphological changes on the pyramidal and granular neurons of the hippocampus in rat brain under different corticosteroid conditions
- Subcellular distribution of lipocortin 1(LC1)in the folliculostellate(FS)cells of rat anterior pituitary following adrenalectomy and corticosterone treatment : A possibility of the role for intercellular communication in the anterior pituitary
- Spin Alignment of the Ground-State Band Levels in Nd and Sm Isotopes Excited in (α, 2nγ) Reactions
- X-Ray and Infrared Emissions from Accreting Magnetic White Dwarfs : A Model for AM Herculis
- Impedance Characteristics of Robots Considering Human Emotions
- Ruptured Aneurysm of the Medial Posterior Choroidal Artery First Demonstrated by the Microcatheter Technique : Case Report
- Plasma prolactin concentrations and copulatory behavior after salsolinol injection in male rats
- Bowen's Disease Involving the Urethra
- Progression of Pancreatitis Prior to Diabetes Onset in WBN/Kob-Leprfa Rats
- Correlations of Observables in Chaotic States of Macroscopic Quantum Systems(General)
- 100. Effect of EEG Arousal upon Photic Driving
- 9. EFFECTS OF VARIOUS PSYCHOTROPIC DRUGS ON ELECTRICAL ACTIVITY OF THE BRAIN AND BEHAVIOR OF THE CAT : (CHLORPROMAZINE, IMIPRAMINE, PHENOBARBITURATE, LSD-25, LAE, JB-336, ATROPINE, DMAE, JB-516)
- Fuzzy Control of Vertical Pneumatic Servo Systems Using Virtual Reference
- The Levels of ^Al
- Protein Sorting and Secretory Granule Formation in Prolactin-Producing Cells in the Anterior Pituitary
- Nonequilibrium Molecular Dynamics Simulation of Electric Conduction(General)
- Species Distribution of Staphylococci in the Nares and Skin of Horses
- Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis
- Molecular Epidemiology of Staphylococcus aureus Isolates from Horses by Pulsed-Field Gel Electrophoresis
- Determination of ionization efficiency of glycated and non-glycated peptides from the N-terminal of hemoglobin β-chain by electrospray ionization mass spectrometry
- Ratio of the Ion Peak Intensity of Glycated to Non-glycated Hexapeptides from the N-Terminal of Hemoglobin β-Chain Measured by LC-ESI Mass Spectrometry (TMS特集号)
- Two New Species of Dipogon (Deuteragenia) (Insecta: Hymenoptera: Pompilidae) from Subtropical Islands of Japan
- Taxonomic studies on the Pompilidae occurring in Japan north of the Ryukyus:Genus Dipogon, subgenus Deuteragenia(Hymenoptera)(Part 3)
- Taxonomic Studies on the Pompilidae Occurring in Japan North of the Ryukyus : Genus Dipogon, Subgenus Deuteragenia (Hymenoptera)(Part 2)(Systematics, Morphology and Evolution)
- Taxonomic Studies on the Pompilidae Occurring in Japan North of the Ryukyus : Genus Dipogon, Subgenus Deuteragenia (Hymenoptera) (Part 1)(Systematics, Morphology and Evolution)
- Long-Time Tail in an Electric Conduction System(The 50th Anniversary of the Alder Transition -Recent Progress on Computational Statistical Physics-)
- Long-Time Behavior of Velocity Autocorrelation Function for Interacting Particles in a Two-Dimensional Disordered System(General)
- Pump Built-in Hamiltonian Method for Pump-probe Spectroscopy
- Sum Rules and Asymptotic Behaviors for Optical Conductivity of Nonequilibrium Many-Electron Systems
- Nectar-collecting Behavior of Queens of Bombus diversus SMITH and B. hypocrita PEREZ (Hymenoptera, Apidae) on the Flowers of Epimedium grandiflorum C. MORR (Berberidaceae)
- Immunohistochemical Localization of the Aquaporins AQP1, AQP3, AQP4, and AQP5 in the Mouse Respiratory System
- Geometrical Aspects of High Energy Inelastic Hadron Reactions
- Systematic studies on the Pompilidae occurring in Japan : Genus Agenioideus Ashmead (Hymenoptera), supplement
- Generalized Phase Rules(General)
- Cleptoparasitic Behavior and Flagellar Sensilla of Poecilagenia sculpturata (Hymenoptera : Pompilidae)
- A STUDY OF THE AGAR GEL DIFFUSION TEST ON MYCOPLASMA GALLISEPTICUM
- Nonequilibrium Molecular Dynamics Simulation of Interacting Many Electrons Scattered by Lattice Vibrations
- A case of monoclonal immunoglobulin G1-lambda deposition associated with membranous feature in a patient with hepatitis C viral infection
- Cluster Property and Robustness of Ground States of Interacting Many Bosons
- Systematic study of the genus Cyphononyx (Hymenoptera : Pompilidae) occurring in Japan
- Indications of Universal Excess Fluctuations in Nonequilibrium Systems
- Universal Properties of Nonlinear Response Functions of Nonequilibrium Steady States
- Isolation and Species Distribution of Staphylococci from Animal and Human Skin.
- Effects of Repeated Administration of Pilocarpine and Isoproterenol on Aquaporin-5 Expression in Rat Salivary Glands
- The effects of gonadal steroid manipulation on the expression of Kiss1 mRNA in rat arcuate nucleus during postnatal development
- Erratum: ``General Properties of Response Functions of Nonequilibrium Steady States''
- Necessity of Superposition of Macroscopically Distinct States for Quantum Computational Speedup
- Morphofunctional changes of the astrocyte in rat hippocampus under different corticosteroid conditions
- A New Drug Evaluation Method for the Treatment of Chronic Pancreatitis Using WBN/Kob Rats as a Model of Human Chronic Pancreatitis.