Locus of Dominant Hairless Gene (Ht) Causing Abnormal Hair and Keratinization Maps to Rat Chromosome 10
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概要
- 論文の詳細を見る
The rat dominant hairless gene (Ht) of the WBN/Ila-Ht rat causes atrichosis in Ht/Ht and hypotrichosis in Ht/+. Furthermore the Ht/Ht shows signs of abnormal keratinization and almost all of the Ht/Ht die in an immature stage before weaning in the conventional environment. Ht/+ was affected by dermatitis caused by Staphylococcus aureus, suggesting that the gene Ht might involve defense mechanisms against infection. In this study, we performed the linkage analysis of the gene Ht by outocross with the Brown Norway rat in the SPF environment. Ninety-six backcross progeny of (BN × WBN/Ila-Ht/Ht) F1 × WBN/Ila-Ht/Ht were typed with microsatellite markers and the gene Ht was mapped on chromosome 10 between Asgr1 and Nos2 within the map distance of 6.2 cM.
- 社団法人 日本実験動物学会の論文
著者
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鈴木 浩悦
日本獣医生命科学大学獣医学部
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SUZUKI Hiroetsu
Department of Veterinary Physiology, Nippon Veterinary and Life Science University
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AKIMOTO Toshio
Division of Laboratory Animal Science, Nippon Medical School
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Akimoto Toshio
Division Of Laboratory Animal Science Nippon Medical School
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NAKAMA Kazumasa
Division of Laboratory Animal Science, Nippon Medical school
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SUZUKI Katsushi
Department of Veterinary Physiology, Nippon Veterinary and Animal Science University
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Suzuki K
Department Of Veterinary Physiology Nippon Veterinary And Animal Science University
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Suzuki Katsushi
Department Of Veterinary Physiology Nippon Veterinary And Zootechnical College
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Suzuki Hiroetsu
Department Of Veterinary Physiology Nippon Veterinary And Animal Science University
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Nakama K
Nippon Medical School Tokyo Jpn
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Suzuki Hodaka
Department Of Veterinary Pathology The University Of Tokyo
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