IL28BとHCV Core aa70置換との関連

概要

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IL28 locus polymorphisms have been reported to affect PEG-IFN plus ribavirin combination therapy for patients with genotype 1b hepatitis C virus (HCV) infection. We examined a relationship between IL28B SNPs (rs8099917 and rs12979860) and amino acid substitutions in core region of HCV in patients with genotype 1b chronic hepatitis C. In each SNP, frequency of core aa 70 mutation was higher rate in female patients carrying minor allele than in male or female patients carrying no minor allele. Measurement of IL28B and Core aa70 before treatment is useful in PEG-IFN plus ribavirin therapy.