Anti Human Immunodeficiency Virus Type 1 (HIV-1) Agents 4. Discovery of 5,5′-(p-Phenylenebisazo)-8-hydroxyquinoline Sulfonates as New HIV-1 Inhibitors in Vitro
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概要
- 論文の詳細を見る
To search for compounds with superior anti-human immunodeficiency virus type 1 (HIV-1) activity, ten 5,5′-(p-phenylenebisazo)-8-hydroxyquinoline sulfonates (4a—j) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Some compounds demonstrated anti-HIV-1 activity, especially 5,5′-(p-phenylenebisazo)-8-hydroxyquinoline p-ethylbenzenesulfonate (4g) and 5,5′-(p-phenylenebisazo)-8-hydroxyquinoline p-chlorobenzenesulfonate (4i) showed the more potent anti-HIV-1 activity with 50% effective concentration (EC50) values of 2.59 and 4.01 μg/ml, and therapeutic index (TI) values of 31.77 and 24.51, respectively.
- 社団法人 日本薬学会の論文
著者
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Xu Hui
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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Xu Hui
Lab. Of Pharmaceutical Synthesis Coll. Of Sciences Northwest A&f Univ.
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Zeng Xi-Wen
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Huang Ning
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yun
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Yang Wen-Bin
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Yang Liu-Meng
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yun
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Qu Huan
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Zheng Yong-Tang
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yun
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A&f University
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Xu Hui
Laboratory Of Lmmunology National Eye Lnstitute National Lnstitutes Of Health
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Yang Liu-meng
Key Lab. Of Animal Models And Human Disease Mechanisms Of The Chinese Acad. Of Sciences & Yunnan
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Zheng Yong-tang
Key Lab. Of Animal Models And Human Disease Mechanisms Of The Chinese Acad. Of Sciences & Yunnan
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Yang Liu-Meng
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
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Huang Ning
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
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Zheng Yong-Tang
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
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Yang Wen-Bin
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Zeng Xi-Wen
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Qu Huan
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Xu Hui
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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