Anti Human Immunodeficiency Virus-1 (HIV-1) Agents 1 : Discovery of Benzyl Phenyl Ethers as New HIV-1 Inhibitors in Vitro
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概要
- 論文の詳細を見る
Ten single benzyl phenyl ethers were synthesized and evaluated as human immunodeficiency virus-1 (HIV-1) inhibitors in vitro for the first time. Among these compounds, especially 4-nitrobenzyl phenyl ether (3h) exhibited the highest anti-HIV-1 activity with EC_<50> (concentration of drug that reduces syncytia formation by 50%) value of 5.96μg/ml and therapeutic index value of 18.32. The preliminary structure-activity relationships of these benzyl phenyl ethers were also described.
- 社団法人日本薬学会の論文
- 2009-01-01
著者
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Zheng Yong-tang
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Xu Hui
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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Liu Wu-qing
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Yang Liu-meng
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Zheng Yong-tang
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Disease Mechani
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Xu Hui
Lab. Of Pharmaceutical Synthesis Coll. Of Sciences Northwest A&f Univ.
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DAI Hui-Ling
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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LV Min
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A&f University
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Lv Min
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Dai Hui-ling
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Lmmunology National Eye Lnstitute National Lnstitutes Of Health
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Lv Min
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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