One-Pot N-Arylation of Indoles Directly from N-Arylsulfonylindoles via Consecutive Deprotection and S_NAr Reactions with Activated Aryl Halides
スポンサーリンク
概要
- 論文の詳細を見る
An efficient one-pot step by step t-BuOK-mediated procedure for the synthesis of N-arylindoles has been developed in moderate to good yields. The protocol involves the consecutive deprotection of N-arylsulfonylindoles as latent indoles and subsequent S_NAr reactions with activated aryl halides. This tandem reaction affords an efficient and convenient preparation of N-arylindoles that benefit from prior indoles protection by arylsulfonyl group, and can shorten a reaction sequence and improve synthetic efficiency.
- 2009-03-01
著者
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Xu Hui
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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FAN Ling-Ling
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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Fan Ling-ling
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Lmmunology National Eye Lnstitute National Lnstitutes Of Health
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Fan Ling-Ling
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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