Synthesis and HIV-1 Integrase Inhibition Activity of some N-Arylindoles
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概要
- 論文の詳細を見る
Eight simple N-arylindoles were designed, synthesized and evaluated as human immunodeficiency virus (HIV)-1 integrase inhibitors in vitro for the first time. Among these compounds, 3b, 3e and 3g demonstrated significant anti-HIV-1 integrase activity. Especially 3b showed the highest anti-HIV-1 integrase activity with EC_<50> value of 7.88μg/ml and TI value of 24.61. Meantime, some structure-activity relationships were also observed and will provide a new lead for design and discovery of more potent N-arylindoles as HIV-1 integrase inhibitors.
- 社団法人日本薬学会の論文
- 2008-05-01
著者
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Zheng Yong-tang
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Xu Hui
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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FAN Ling-Ling
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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Liu Wu-qing
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Yang Liu-meng
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Zheng Yong-tang
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Disease Mechani
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Fan Ling-ling
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Lab. Of Pharmaceutical Synthesis Coll. Of Sciences Northwest A&f Univ.
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CHEN Yang
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University
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LV Lei
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A&f University
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Lv Lei
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A&f University
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Xu Hui
Laboratory Of Lmmunology National Eye Lnstitute National Lnstitutes Of Health
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Chen Yang
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A&f University
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Fan Ling-Ling
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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