Anti Human Immunodeficiency Virus-1 (HIV-1) Agents 3. Synthesis and in Vitro Anti-HIV-1 Activity of Some N-Arylsulfonylindoles
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概要
- 論文の詳細を見る
In order to find compounds with superior anti human immunodeficiency virus type 1 (HIV-1) activity, twelve simple N-arylsulfonylindoles (3a—l) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Several compounds demonstrated significant anti-HIV-1 activity, especially N-(3-nitrobenzene)sulfonyl-6-methylindole (3h) and N-(3-nitrobenzene)sulfonylindole (3i) showed the highest anti-HIV-1 activity with EC50 values of 0.26 and 0.74 μg/ml, and TI values of 543.78 and >270.27, respectively.
- 社団法人 日本薬学会の論文
著者
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Zheng Yong-tang
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Xu Hui
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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FAN Ling-Ling
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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Liu Wu-qing
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Yang Liu-meng
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Diseases Mechan
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Zheng Yong-tang
Laboratory Of Molecular Immunopharmacology Key Laboratory Of Animal Models And Human Disease Mechani
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Fan Ling-ling
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Lab. Of Pharmaceutical Synthesis Coll. Of Sciences Northwest A&f Univ.
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LV Min
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A & F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A&f University
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Lv Min
Laboratory Of Pharmaceutical Synthesis College Of Sciences Northwest A & F University
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Xu Hui
Laboratory Of Lmmunology National Eye Lnstitute National Lnstitutes Of Health
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Fan Ling-Ling
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Zheng Yong-Tang
Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences
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YANG Liu-Meng
Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences
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Liu Wu-Qing
Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences
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Xu Hui
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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Lv Min
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University
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