Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

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概要

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• A total of 36 compounds (1—36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (−)-5,4′-dihydroxy-7,8-[(3″,4″-cis-dihydroxy-3″,4″-dihydro)-2″,2″-dimethylpyrano]-flavone (1), (−)-5,4′-dihydroxy-7,8-[(3″-hydroxy-4″-one)-2″,2″-dimethylpyrano]-flavone (2), and (−)-5,4′-dihydroxy-7,8-[(cis-3″-hydroxy-4″-ethoxy-3″,4″-dihydro)-2″,2″-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1—20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (TI) of 143.65.

• 公益社団法人　日本薬学会の論文

著者

• Zheng Yong-Tang

  Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yun

• Wang Rui-Rui

  Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharm

• Feng Tao

  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan

• Cai Xiang-Hai

  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan

• Luo Xiao-Dong

  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan

• Zheng Yong-tang

  Key Lab. Of Animal Models And Human Disease Mechanisms Of The Chinese Acad. Of Sciences & Yunnan

• Feng Tao

  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

関連論文

• Anti Human Immunodeficiency Virus Type 1 (HIV-1) Agents 4. Discovery of 5,5′-(p-Phenylenebisazo)-8-hydroxyquinoline Sulfonates as New HIV-1 Inhibitors in Vitro
• Chemical Constituents from the Leaves and Stems of Schisandra lancifolia
• Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata
• Neolignans from Schisandra wilsoniana and Their Anti-human Immunodeficiency Virus-1 Activities

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