Biocatalytic Synthesis of Dihydroxynaphthoic Acids by Cytochrome P450 CYP199A2
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概要
- 論文の詳細を見る
CYP199A2, a bacterial P450 monooxygenase from Rhodopseudomonas palustris, was found to exhibit oxidation activity towards three hydroxynaphthoic acids. Whole cells of the recombinant Escherichia coli strain expressing CYP199A2 efficiently catalyzed the regioselective oxidation of 1-, 3-, and 6-hydroxy-2-naphthoic acids to produce 1,7-, 3,7-, and 6,7-dihydroxynaphthoic acid respectively. These results suggest that CYP199A2 might be a useful oxidation biocatalyst for the synthesis of dihydroxynaphthoic acids.
- 社団法人 日本農芸化学会の論文
著者
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Kino Kuniki
Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University
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Furuya Toshiki
Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University
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