Gamma/Delta T Cell Lymphoma
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概要
- 論文の詳細を見る
A 54-year-old woman complained of fever and hepatosplenomegaly. The pathological findings of a liver biopsy specimen revealed the infiltration of lymphocytes in the sinusoids and that of the laparoscopically resected spleen revealed the infiltration of lymphocytes in the red pulp, which was positive for CD3, CD43, CD45RO and T-cell intracellular antigen-1 (TIA-1) and was negative for βF1, while the white pulp was spared. Genetic analysis of the spleen cells revealed the rearrangement of T-cell receptor (TCR) Cβ1, Jδ1 and Jγ. Epstein-Barr virus (EBV) genomic DNA was detected in the spleen cells. Atypical lymphocytes appeared in the peripheral blood and bone marrow, chromosomal analysis revealed del (13) (q12 q14), trisomy 8 and breakage of RB gene. Elevated level of serum vascular endothelial growth factor (VEGF) was observed. Hepatosplenic γδ T cell lymphoma (GDTL) was diagnosed. The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.
- 社団法人 日本内科学会の論文
- 2004-02-01
著者
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Shinohara Kenji
Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center
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INOUE Yusuke
Department of Radiology, Institute of Medical Sciences, University of Tokyo
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Taguchi Akihiko
山口県立総合医療センター
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Taguchi A
Yamaguchi Prefecture Central Hospital Yamaguchi Jpn
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Kamei Toshiaki
Departments Of Pathology Yamaguchi Central Hospital
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Kamei Toshiaki
Department Of Pathology Yamaguchi Prefectural Central Hospital
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Inoue Yusuke
Department Of Radiology Institute Of Medical Science University Of Tokyo
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Sakuragi Shizu
Department of Internal Medicine, Yamaguchi Prefecture General Hospital
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Miyazaki Mutsuko
Department of Internal Medicine, Yamaguchi Prefecture General Hospital
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Shinohara Kenji
Division Of Hematology Department Of Medicine Yamaguchi Prefectural Medical Center
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TAGUCHI Akihiko
Division of Hematology, Department of Medicine
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MIYAZAKI Mutsuko
Division of Hematology, Department of Medicine
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SAKURAGI Shizu
Division of Hematology, Department of Medicine
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Inoue Yasushi
Department Of Internal Medicine Yamaguchi Prefecture General Hospital
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Miyazaki Mutsuko
Department Of Internal Medicine Yamaguchi Prefecture General Hospital
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Inoue Yusuke
Department Of Biomedical Engineering Graduate School Of Medicine The University Of Tokyo
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Kamei Toshiaki
Department Of Pathology Yamaguchi Central Hospital
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Shinohara Kenji
Division Of Hematology Department Of Medicine
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Sakuragi Shizu
Department Of Internal Medicine Yamaguchi Prefecture General Hospital
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Taguchi Akihiko
Department Of Internal Medicine Yamaguchi Prefecture General Hospital
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Shinohara Kenji
Division of Environment and Radiation Science, Nuclear Science and Energy Directions, Japan Atomic Energy Agency
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