Angioimmunoblastic T Cell Lymphoma Associated with Reversible Myelofibrosis
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概要
- 論文の詳細を見る
A 56-year-old man complained of fever, anemia, thrombocytopenia and lymph node swelling. Biopsy of the lymph node demonstrated angioimmunoblastic T cell lymphoma (AITL) with the loss of normal architecture, proliferation of neoplastic T cells, small vessels mixed with eosinophils and plasma cells. Aspiration of bone marrow was dry tap, and biopsy demonstrated myelofibrosis with increased proliferation of reticulin fiber. Markedly elevated plasma levels of transforming growth factor β1 (TGF-β1) and soluble interleukin-2 receptor (sIL-2R) were observed, and that of platelet growth factor (PDGF) AB was slightly elevated. After chemotherapy, remission of lymphoma was achieved. The aspiration of bone marrow became possible, and the level of TGF-β1 and PDGF AB showed normalization; thus, myelofibrosis was reversible.
- 社団法人 日本内科学会の論文
著者
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Tominaga Takayuki
Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center
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Matsui Kumiko
Division Of Hematology Department Of Medicine Yamaguchi Prefectural Medical Center
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Kamei Toshiaki
Department Of Pathology Yamaguchi Central Hospital
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Adachi Mayumi
Division Of Hematology Department Of Medicine Yamaguchi Prefectural Medical Center
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Shinohara Kenji
Division of Environment and Radiation Science, Nuclear Science and Energy Directions, Japan Atomic Energy Agency
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Kamei Toshiaki
Department of Pathology, Yamaguchi Prefectural Medical Center
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