Curative Effect of Combined Treatment With Alendronate and 1α-Hydroxyvitamin D_3 on Bone Loss by Ovariectomy in Aged Rats

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概要

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• We investigated the combined effects of alendronate and 1α-hydroxyvitamin D3 (1α(OH)D3) on the bone mass and strength in aged ovariectomized rats and compared them with those of single treatments. Forty-week-old female rats underwent ovariectomy or sham operation, and after 15 weeks, ovariectomized rats were daily administered vehicle alone, alendronate (0.2 or 1.0 mg/kg, p.o.), 1α(OH)D3 (0.02 μg/kg, p.o.), or the combinations of 0.2 or 1.0 mg/kg of alendronate and 1α(OH)D3. After 12 weeks, the groups receiving combined treatments had significantly increased bone density and mechanical strength of the 4th lumbar vertebral body and the midfemur compared to the vehicle-treated group, and the effects were almost equal to or slightly less than the addition of those of the respective single treatments. The increase in mechanical strength was proportional to that in bone mineral density, suggesting that the stimulatory effects of these treatments on bone strength are ascribable primarily to those on bone mass. Analyses of histology, computed tomography, and biochemical markers confirmed the strong effect of the combined treatment on trabecular bone in particular, which was associated with increased trabecular number and decreased bone turnover. We propose that the combination of daily alendronate and 1α(OH)D3 is clinically promising as a curative treatment of established postmenopausal osteoporosis.

• 社団法人 日本薬理学会の論文
• 2002-07-01

著者

• KAWAGUCHI Hiroshi

  Department of Orthopaedic Surgery, The University of Tokyo

• OHTA Tomohiro

  Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Insti

• KOMORIYA Keiji

  Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Insti

• Kawaguchi Hiroshi

  Department Of Chemistry Faculty Of Science Kochi University

• Ito Masaya

  Pharmacological Resarch Department Teijin Institute For Bio-medical Research Teijin Ltd.

• Ohta Tomohiro

  Pharmacological Resarch Department Teijin Institute For Bio-medical Research Teijin Ltd.

• Azuma Yoshiaki

  Pharmacological Resarch Department Teijin Institute For Bio-medical Research Teijin Ltd.

• Komoriya K

  Pharmacological Resarch Department Teijin Institute For Bio-medical Research Teijin Ltd.

• Komoriya Keiji

  Pharmacological Research Department Pharmaceuticals Development Research Laboratories Teijin Institu

• TAKAGI Hideko

  Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Insti

• Kamei H

  Department Of Orthopedic Surgery Graduate School Of Medicine University Of Tokyo

• Takagi Hideko

  Pharmacological Resarch Department Teijin Institute For Bio-medical Research Teijin Ltd.

• Kawaguchi Hiroshi

  Department Of Applied Chemistry Faculty Of Engineering Utsunomiya University

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